The development and in vivo evaluation of a colon drug delivery system using human volunteers

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F12%3A00102456" target="_blank" >RIV/00843989:_____/12:00102456 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62157124:16370/12:43871001

Výsledek na webu

<a href="http://dx.doi.org/10.3109/10717544.2011.644350" target="_blank" >http://dx.doi.org/10.3109/10717544.2011.644350</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3109/10717544.2011.644350" target="_blank" >10.3109/10717544.2011.644350</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The development and in vivo evaluation of a colon drug delivery system using human volunteers

Popis výsledku v původním jazyce

The aim of this study was to develop a multiple-unit dosage system that released model drug into the colon, and also to evaluate the efficiency of the dosage form in human volunteers. The developed system combines pH-, time- and biodegradable polymer-based mechanisms for drug targeting to the colon. Pellet cores containing caffeine as model drug and chitosan and microcrystalline cellulose as excipients were prepared by the extrusion/spheronization method. The prepared pellets were film coated with a pH-dependent polymer, Eudragit FS 30 D. The coating total weight gain was 28.83% (w/w). Thanks to the application of an outer enteric film and the multiple unit design of the dosage form, the variability in gastric emptying was overcome, and a colon-specific targeting relied on the reproducibility of a small intestinal transit time, which was reported to be 3 +/- 1 hours. A biodegradable polymer in the pellet core, chitosan, ensured the site-specific release of the model drug due to its sol

Název v anglickém jazyce

The development and in vivo evaluation of a colon drug delivery system using human volunteers

Popis výsledku anglicky

The aim of this study was to develop a multiple-unit dosage system that released model drug into the colon, and also to evaluate the efficiency of the dosage form in human volunteers. The developed system combines pH-, time- and biodegradable polymer-based mechanisms for drug targeting to the colon. Pellet cores containing caffeine as model drug and chitosan and microcrystalline cellulose as excipients were prepared by the extrusion/spheronization method. The prepared pellets were film coated with a pH-dependent polymer, Eudragit FS 30 D. The coating total weight gain was 28.83% (w/w). Thanks to the application of an outer enteric film and the multiple unit design of the dosage form, the variability in gastric emptying was overcome, and a colon-specific targeting relied on the reproducibility of a small intestinal transit time, which was reported to be 3 +/- 1 hours. A biodegradable polymer in the pellet core, chitosan, ensured the site-specific release of the model drug due to its sol

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Drug Delivery

ISSN

1071-7544

e-ISSN

—

Svazek periodika

19

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

81-89

Kód UT WoS článku

000299745700001

EID výsledku v databázi Scopus

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