Cytochrome P450 2D6 phenotype and genotype in hypertensive patients on long-term therapy with metoprolol
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F13%3A00103180" target="_blank" >RIV/00843989:_____/13:00103180 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/61988987:17110/13:A14019VE
Výsledek na webu
<a href="http://dx.doi.org/10.4149/BLL_2013_043" target="_blank" >http://dx.doi.org/10.4149/BLL_2013_043</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4149/BLL_2013_043" target="_blank" >10.4149/BLL_2013_043</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Cytochrome P450 2D6 phenotype and genotype in hypertensive patients on long-term therapy with metoprolol
Popis výsledku v původním jazyce
Objective: The aim was to compare cytochrome P450 2D6 phenotype and genotype using metoprolol as a probe drug. Further, to investigate the influence of P450 2D6 activity on metoprolol pharmacokinetics and pharmacodynamics in patients on metoprolol therapy. Background: Cytochrome P450 2D6 is a highly polymorphic enzyme that contributes to the variability of metoprolol. However, environmental factors also modify drug disposition. Methods: Forty-nine hypertensive patients were enrolled. Serum metoprolol and &#945;-hydroxymetoprolol concentrations, resting heart rate were measured before, 1, 3 and 4 hours post-dose. Results: Significantly higher normalized metoprolol serum concentrations, normalized metoprolol AUC0-4 and metoprolol oral clearance wereobserved in patients with lower P450 2D6 metabolic activity. A trend towards a lower resting heart rate before metoprolol intake was also observed in this group of patients. The differences in metoprolol disposition were more expressed wh
Název v anglickém jazyce
Cytochrome P450 2D6 phenotype and genotype in hypertensive patients on long-term therapy with metoprolol
Popis výsledku anglicky
Objective: The aim was to compare cytochrome P450 2D6 phenotype and genotype using metoprolol as a probe drug. Further, to investigate the influence of P450 2D6 activity on metoprolol pharmacokinetics and pharmacodynamics in patients on metoprolol therapy. Background: Cytochrome P450 2D6 is a highly polymorphic enzyme that contributes to the variability of metoprolol. However, environmental factors also modify drug disposition. Methods: Forty-nine hypertensive patients were enrolled. Serum metoprolol and &#945;-hydroxymetoprolol concentrations, resting heart rate were measured before, 1, 3 and 4 hours post-dose. Results: Significantly higher normalized metoprolol serum concentrations, normalized metoprolol AUC0-4 and metoprolol oral clearance wereobserved in patients with lower P450 2D6 metabolic activity. A trend towards a lower resting heart rate before metoprolol intake was also observed in this group of patients. The differences in metoprolol disposition were more expressed wh
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FR - Farmakologie a lékárnická chemie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Ostatní
Rok uplatnění
2013
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Bratislavské lekárske listy
ISSN
0006-9248
e-ISSN
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Svazek periodika
114
Číslo periodika v rámci svazku
n. 4
Stát vydavatele periodika
SK - Slovenská republika
Počet stran výsledku
7
Strana od-do
"p. 206-212"
Kód UT WoS článku
000318058700005
EID výsledku v databázi Scopus
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