Comparison of metoprolol/-hydroxymetoprolol metabolic ratio after a single dose and in steady state
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F10%3AA110109A" target="_blank" >RIV/61988987:17110/10:A110109A - isvavai.cz</a>
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Comparison of metoprolol/-hydroxymetoprolol metabolic ratio after a single dose and in steady state
Popis výsledku v původním jazyce
Metoprolol/alfa-hydroxymetoprolol metabolic ratio (MR) 3 hours after a single metoprolol dose is used for cytochrome P450 2D6 phenotyping. The aim was to compare cytochrome P450 2D6 metabolic activity after the first metoprolol dose and in steady state.Thirteen adult hypertinsive patients (7 females) in whom an antroduction of the beta-blocker metoprolol was indicated were included. Age (mean ? SD) was 42,8 ? 12,9 years, weight (mean ? SD) was 94,0 ? 25,4 kg. Metoprolol dose was chosen based on clinical grounds on the day of metoprolol first ingestion. Blood samples were drawn after the first dose and at least 2 weeks since metoprolol introduction to ensure steady state. The patients were phenotyped as extensive metabolizers in both periods, after metoprolol first ingestion and in steady state. We observed a significant correlation (rs = 0,8418, P = 0,0003) between the metoprolol/alfa-hydroxymetoprolol MRs.
Název v anglickém jazyce
Comparison of metoprolol/-hydroxymetoprolol metabolic ratio after a single dose and in steady state
Popis výsledku anglicky
Metoprolol/alfa-hydroxymetoprolol metabolic ratio (MR) 3 hours after a single metoprolol dose is used for cytochrome P450 2D6 phenotyping. The aim was to compare cytochrome P450 2D6 metabolic activity after the first metoprolol dose and in steady state.Thirteen adult hypertinsive patients (7 females) in whom an antroduction of the beta-blocker metoprolol was indicated were included. Age (mean ? SD) was 42,8 ? 12,9 years, weight (mean ? SD) was 94,0 ? 25,4 kg. Metoprolol dose was chosen based on clinical grounds on the day of metoprolol first ingestion. Blood samples were drawn after the first dose and at least 2 weeks since metoprolol introduction to ensure steady state. The patients were phenotyped as extensive metabolizers in both periods, after metoprolol first ingestion and in steady state. We observed a significant correlation (rs = 0,8418, P = 0,0003) between the metoprolol/alfa-hydroxymetoprolol MRs.
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FR - Farmakologie a lékárnická chemie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2010
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
česká a slovenská farmacie
ISSN
1210-7816
e-ISSN
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Svazek periodika
5
Číslo periodika v rámci svazku
59
Stát vydavatele periodika
CZ - Česká republika
Počet stran výsledku
5
Strana od-do
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Kód UT WoS článku
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EID výsledku v databázi Scopus
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