Lymphangiogenesis and its correlation with the VEGF expression and the sentinel lymph node in cutaneous melanomas

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F14%3AE0104072" target="_blank" >RIV/00843989:_____/14:E0104072 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61988987:17110/14:A1501BTG

Výsledek na webu

<a href="http://dx.doi.org/10.1155/2014/372979" target="_blank" >http://dx.doi.org/10.1155/2014/372979</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1155/2014/372979" target="_blank" >10.1155/2014/372979</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Lymphangiogenesis and its correlation with the VEGF expression and the sentinel lymph node in cutaneous melanomas

Popis výsledku v původním jazyce

The aim of the study is to evaluate the density of intratumoral and peritumoral lymphatic vessels in primary cutaneous melanomas and to assess their correlation with the status of sentinel lymph nodes and the VEGF expression in tumor cells and stromal cells. A total of 40 patients were enrolled in the study: the melanomas were radically excised with the extirpation of the sentinel lymph node. The study subjects were divided into two groups: 20 cases with positive and 20 cases with negative sentinel lymph node results. The density of lymphatic vessels was evaluated by the antibody D2-40 and the VEGF expression was investigated in the semiquantitative way. The VEGF expression in melanoma cells and the stromal cells was negative to variable positive at both SLN negative and SLN positive patients in all pT stages. In the group of SLN positive patients, the density of intratumoral lymphatic vessels was low up to moderate, while it was observed to be absent, somewhere on the low level in the

Název v anglickém jazyce

Lymphangiogenesis and its correlation with the VEGF expression and the sentinel lymph node in cutaneous melanomas

Popis výsledku anglicky

The aim of the study is to evaluate the density of intratumoral and peritumoral lymphatic vessels in primary cutaneous melanomas and to assess their correlation with the status of sentinel lymph nodes and the VEGF expression in tumor cells and stromal cells. A total of 40 patients were enrolled in the study: the melanomas were radically excised with the extirpation of the sentinel lymph node. The study subjects were divided into two groups: 20 cases with positive and 20 cases with negative sentinel lymph node results. The density of lymphatic vessels was evaluated by the antibody D2-40 and the VEGF expression was investigated in the semiquantitative way. The VEGF expression in melanoma cells and the stromal cells was negative to variable positive at both SLN negative and SLN positive patients in all pT stages. In the group of SLN positive patients, the density of intratumoral lymphatic vessels was low up to moderate, while it was observed to be absent, somewhere on the low level in the

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

BioMed research international

ISSN

2314-6133

e-ISSN

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Svazek periodika

2014

Číslo periodika v rámci svazku

n. Article ID 372979

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

"p. 1-6"

Kód UT WoS článku

000338555200001

EID výsledku v databázi Scopus

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