Diagnostic accuracy of cystatin C and creatinine based estimation of glomerular filtration using various equations in pediatrics

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Diagnostic accuracy of cystatin C and creatinine based estimation of glomerular filtration using various equations in pediatrics

Popis výsledku v původním jazyce

Introduction: The glomerular filtration rate (eGFR) is an important parameter for assessing renal function. The preferred methods for determining eGFR involve calculations using equations based on serum creatinine (Cr), cystatin C (CC) or a combination of these two biochemical markers without urine collection. Objectives: The aim of the study was to compare different equations to estimate GFR in children and to select the most optimal equation. Methods: We examined a group of 133 children from the Nephrology Outpatients of the Department of Paediatrics of University Hospital Ostrava. Serum samples were used to analyse Cr and CC. Statistical evaluation of results was performed using QC Expert and R software. Results: We examined six CC-based, four Cr-based and two Cr-and CC-based prediction equations. At the same time, all of the equations did not provide falsely high values of eGFR even at low values of CC. In the case of Cr-based eGFR equations, the CKD EPI equation correlated best with serum Cr and together with the Lund-Malmö equation did not provide falsely high values of eGFR. The correlation coefficients of CC- and Cr-based equations were comparable and CKD-EPI gave better results than the Zappitelli equation when assessing the resulting values of eGFR. The trueness of the equations for estimating eGFR values was assessed based on the median of all the equations. All medians of CC-based equations for eGFR were not significantly different with the exception of the KDIGO equation, which gave up to 23% lower values of bias. Of the Cr-based equations, the CKD-EPI equation provided up to 30% higher values of bias, while the Lund-Malmö equation provided much better results. The Schwartz and Counahan-Barratt equations provide at low concentrations of Cr comparable results with falsely positive values of eGFR. Conclusions: We conclude that the trueness of various CC-based equations provides comparable GFR levels as do combined CC- and Cr-based equations.

Název v anglickém jazyce

Diagnostic accuracy of cystatin C and creatinine based estimation of glomerular filtration using various equations in pediatrics

Popis výsledku anglicky

Introduction: The glomerular filtration rate (eGFR) is an important parameter for assessing renal function. The preferred methods for determining eGFR involve calculations using equations based on serum creatinine (Cr), cystatin C (CC) or a combination of these two biochemical markers without urine collection. Objectives: The aim of the study was to compare different equations to estimate GFR in children and to select the most optimal equation. Methods: We examined a group of 133 children from the Nephrology Outpatients of the Department of Paediatrics of University Hospital Ostrava. Serum samples were used to analyse Cr and CC. Statistical evaluation of results was performed using QC Expert and R software. Results: We examined six CC-based, four Cr-based and two Cr-and CC-based prediction equations. At the same time, all of the equations did not provide falsely high values of eGFR even at low values of CC. In the case of Cr-based eGFR equations, the CKD EPI equation correlated best with serum Cr and together with the Lund-Malmö equation did not provide falsely high values of eGFR. The correlation coefficients of CC- and Cr-based equations were comparable and CKD-EPI gave better results than the Zappitelli equation when assessing the resulting values of eGFR. The trueness of the equations for estimating eGFR values was assessed based on the median of all the equations. All medians of CC-based equations for eGFR were not significantly different with the exception of the KDIGO equation, which gave up to 23% lower values of bias. Of the Cr-based equations, the CKD-EPI equation provided up to 30% higher values of bias, while the Lund-Malmö equation provided much better results. The Schwartz and Counahan-Barratt equations provide at low concentrations of Cr comparable results with falsely positive values of eGFR. Conclusions: We conclude that the trueness of various CC-based equations provides comparable GFR levels as do combined CC- and Cr-based equations.

Druh

D - Stať ve sborníku

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

CECE 2014. 11th International Interdisciplinary Meeting on Bioanalysis. October 20-22, 2014

ISBN

978-80-904959-2-0

ISSN

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e-ISSN

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Počet stran výsledku

4

Strana od-do

"P. 306-309"

Název nakladatele

Institut of Analytical Chemistry ASCR

Místo vydání

Brno

Místo konání akce

Brno, Czech Republic

Datum konání akce

20. 10. 2014

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

000354547400099