Cerebellar dysfunction and ataxia in patients with epilepsy: coincidence, consequence, or cause?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F16%3AE0106002" target="_blank" >RIV/00843989:_____/16:E0106002 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/16:00092463

Výsledek na webu

<a href="http://dx.doi.org/10.7916/D8KH0NBT" target="_blank" >http://dx.doi.org/10.7916/D8KH0NBT</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.7916/D8KH0NBT" target="_blank" >10.7916/D8KH0NBT</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Cerebellar dysfunction and ataxia in patients with epilepsy: coincidence, consequence, or cause?

Popis výsledku v původním jazyce

Basic epilepsy teachings assert that seizures arise from the cerebral cortex, glossing over infratentorial structures such as the cerebellum that are believed to modulate rather than generate seizures. Nonetheless, ataxia and other clinical findings in epileptic patients are slowly but inevitably drawing attention to this neural node. Tracing the evolution of this line of inquiry from the observed coincidence of cerebellar atrophy and cerebellar dysfunction (most apparently manifested as ataxia) in epilepsy to their close association, this review considers converging clinical, physiological, histological, and neuroimaging evidence that support incorporating the cerebellum into epilepsy pathology. We examine reports of still controversial cerebellar epilepsy, studies of cerebellar stimulation alleviating paroxysmal epileptic activity, studies and case reports of cerebellar lesions directly associated with seizures, and conditions in which ataxia is accompanied by epileptic seizures. Finally, the review substantiates the role of this complex brain structure in epilepsy whether by coincidence, as a consequence of deleterious cortical epileptic activity or antiepileptic drugs, or the very cause of the disease.

Název v anglickém jazyce

Cerebellar dysfunction and ataxia in patients with epilepsy: coincidence, consequence, or cause?

Popis výsledku anglicky

Basic epilepsy teachings assert that seizures arise from the cerebral cortex, glossing over infratentorial structures such as the cerebellum that are believed to modulate rather than generate seizures. Nonetheless, ataxia and other clinical findings in epileptic patients are slowly but inevitably drawing attention to this neural node. Tracing the evolution of this line of inquiry from the observed coincidence of cerebellar atrophy and cerebellar dysfunction (most apparently manifested as ataxia) in epilepsy to their close association, this review considers converging clinical, physiological, histological, and neuroimaging evidence that support incorporating the cerebellum into epilepsy pathology. We examine reports of still controversial cerebellar epilepsy, studies of cerebellar stimulation alleviating paroxysmal epileptic activity, studies and case reports of cerebellar lesions directly associated with seizures, and conditions in which ataxia is accompanied by epileptic seizures. Finally, the review substantiates the role of this complex brain structure in epilepsy whether by coincidence, as a consequence of deleterious cortical epileptic activity or antiepileptic drugs, or the very cause of the disease.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FH - Neurologie, neurochirurgie, neurovědy

OECD FORD obor

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Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Tremor and other hyperkinetic movements

ISSN

2160-8288

e-ISSN

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Svazek periodika

6

Číslo periodika v rámci svazku

n. June

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

12

Strana od-do

"p. 1-12"

Kód UT WoS článku

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EID výsledku v databázi Scopus

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