Total and high-molecular-weight adiponectin levels and prediction of insulin resistance

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F18%3AE0107611" target="_blank" >RIV/00843989:_____/18:E0107611 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15110/18:73588588

Výsledek na webu

<a href="https://journals.viamedica.pl/endokrynologia_polska/article/view/56885" target="_blank" >https://journals.viamedica.pl/endokrynologia_polska/article/view/56885</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.5603/EP.a2018.0035" target="_blank" >10.5603/EP.a2018.0035</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Total and high-molecular-weight adiponectin levels and prediction of insulin resistance

Popis výsledku v původním jazyce

Introduction: Adiponectin is a peptide secreted by adipocytes; its reduction is associated with obesity-related disorders, including insulin resistance (IR). The study analysed levels of total adiponectin and its high-molecular-weight (HMW) oligomer in a group of metabolically healthy adults and in patients with type 2 diabetes mellitus (T2DM) to evaluate these levels as potential predictors of the presence of IR. Materials and methods: The study comprised 269 metabolically healthy adults and 300 patients with T2DM. Anthropometric and biochemical indices were measured, including total and HMW adiponectin levels; the Homeostatic Model Assessment of IR (HOMA-IR) index was calculated, and logistic regression analysis was used to predict the presence of IR. Results: In healthy individuals, both total and HMW adiponectin levels were significantly higher than in diabetic patients. Total and HMW adiponectin levels were moderately correlated with the HOMA-IR index. Logistic regression analysis showed that increased levels of both total adiponectin (odds ratio [OR] 0.598, 95% confidence interval [CI] 0.483–0.723) and the HMW form (OR 0.360, 95% CI 0.242–0.511) are protective factors for the development of IR. The cut-off levels were 4.22 mg/L for total adiponectin and 2.75 mg/L for HMW adiponectin. The results are valid for middle-aged European adults. Conclusions: Adiponectin levels below the indicated cut-offs may predict a potential risk for the development of IR.

Název v anglickém jazyce

Total and high-molecular-weight adiponectin levels and prediction of insulin resistance

Popis výsledku anglicky

Introduction: Adiponectin is a peptide secreted by adipocytes; its reduction is associated with obesity-related disorders, including insulin resistance (IR). The study analysed levels of total adiponectin and its high-molecular-weight (HMW) oligomer in a group of metabolically healthy adults and in patients with type 2 diabetes mellitus (T2DM) to evaluate these levels as potential predictors of the presence of IR. Materials and methods: The study comprised 269 metabolically healthy adults and 300 patients with T2DM. Anthropometric and biochemical indices were measured, including total and HMW adiponectin levels; the Homeostatic Model Assessment of IR (HOMA-IR) index was calculated, and logistic regression analysis was used to predict the presence of IR. Results: In healthy individuals, both total and HMW adiponectin levels were significantly higher than in diabetic patients. Total and HMW adiponectin levels were moderately correlated with the HOMA-IR index. Logistic regression analysis showed that increased levels of both total adiponectin (odds ratio [OR] 0.598, 95% confidence interval [CI] 0.483–0.723) and the HMW form (OR 0.360, 95% CI 0.242–0.511) are protective factors for the development of IR. The cut-off levels were 4.22 mg/L for total adiponectin and 2.75 mg/L for HMW adiponectin. The results are valid for middle-aged European adults. Conclusions: Adiponectin levels below the indicated cut-offs may predict a potential risk for the development of IR.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30202 - Endocrinology and metabolism (including diabetes, hormones)

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Endokrynologia Polska

ISSN

0423-104X

e-ISSN

—

Svazek periodika

69

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

PL - Polská republika

Počet stran výsledku

6

Strana od-do

375-380

Kód UT WoS článku

000444730200004

EID výsledku v databázi Scopus

2-s2.0-85055836105