Serum neurofilament light chain levels in patients with cognitive deficits and movement disorders:comparison of cerebrospinal and serum neurofilament light chain levels with other biomarkers

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F23%3AE0110562" target="_blank" >RIV/00843989:_____/23:E0110562 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61988987:17110/23:A2402NOS

Výsledek na webu

<a href="https://www.frontiersin.org/articles/10.3389/fnhum.2023.1284416/full?&utm_source=Email_to_authors_&utm_medium=Email&utm_content=T1_11.5e1_author&utm_campaign=Email_publication&field=&journalName=Frontiers_in_Human_Neuroscience&id=1284416" target="_blank" >https://www.frontiersin.org/articles/10.3389/fnhum.2023.1284416/full?&utm_source=Email_to_authors_&utm_medium=Email&utm_content=T1_11.5e1_author&utm_campaign=Email_publication&field=&journalName=Frontiers_in_Human_Neuroscience&id=1284416</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fnhum.2023.1284416" target="_blank" >10.3389/fnhum.2023.1284416</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Serum neurofilament light chain levels in patients with cognitive deficits and movement disorders:comparison of cerebrospinal and serum neurofilament light chain levels with other biomarkers

Popis výsledku v původním jazyce

Background: Serum neurofilament light chain (S NfL) is a non-specific marker of neuronal damage, including Alzheimer’s disease (AD). We aimed to verify the reference interval (RI) of serum NfL using a highly sensitive ELISA, and to estimate the optimal cut-off value for neuronal damage. Our second objective was to compare NfL in cerebrospinal fluid (CSF) and serum (S) with the routine neurodegeneration biomarkers used in AD, and to assess their concentrations relative to the degree of cognitive deficit. Methods: Samples from 124 healthy volunteers were used to estimate the S NfL RI. For the comparison study, we used CSF and S samples from 112 patients with cognitive disorders. Cognitive functions were assessed using the mini-mental state examination. ELISA assays were used to determine the CSF and S NfL levels, CSF ß-amyloid peptide42 (Aß42), CSF ß-amyloid peptide40 (Aß40), CSF total tau protein (tTau), CSF phosphorylated tau protein (pTau), and CSF alpha-synuclein (?S). Results: The estimated RI of S NfL were 2.25–9.19 ng.L–1. The cut-off value of S NfL for assessing the degree of neuronal impairment was 10.5 ng.L–1. We found a moderate statistically significant correlation between S NfL and CSF Aß42 in the group with movement disorders, without dementia (rs = 0.631; p = 0.016); between S NfL and CSF Aß40 in the group with movement disorder plus dementia (rs = -0.750; p = 0.052); between S NfL and CSF tTau in the control group (rs = 0.689; p = 0.009); and between S NfL and CSF pTau in the control group (rs = 0.749; p = 0.003). The non-parametric Kruskal–Wallis test revealed statistically significant differences between S NfL, CSF NfL, CSF Aß42, CSF tTau, and CSF pTau and diagnosis within groups. The highest kappa coefficients were found between the concentrations of S NfL and CSF NfL (? = 0.480) and between CSF NfL and CSF tTau (? = 0.351). Conclusion: Our results suggested that NfL and tTau in CSF of patients with cognitive decline could be replaced by the less...

Název v anglickém jazyce

Serum neurofilament light chain levels in patients with cognitive deficits and movement disorders:comparison of cerebrospinal and serum neurofilament light chain levels with other biomarkers

Popis výsledku anglicky

Background: Serum neurofilament light chain (S NfL) is a non-specific marker of neuronal damage, including Alzheimer’s disease (AD). We aimed to verify the reference interval (RI) of serum NfL using a highly sensitive ELISA, and to estimate the optimal cut-off value for neuronal damage. Our second objective was to compare NfL in cerebrospinal fluid (CSF) and serum (S) with the routine neurodegeneration biomarkers used in AD, and to assess their concentrations relative to the degree of cognitive deficit. Methods: Samples from 124 healthy volunteers were used to estimate the S NfL RI. For the comparison study, we used CSF and S samples from 112 patients with cognitive disorders. Cognitive functions were assessed using the mini-mental state examination. ELISA assays were used to determine the CSF and S NfL levels, CSF ß-amyloid peptide42 (Aß42), CSF ß-amyloid peptide40 (Aß40), CSF total tau protein (tTau), CSF phosphorylated tau protein (pTau), and CSF alpha-synuclein (?S). Results: The estimated RI of S NfL were 2.25–9.19 ng.L–1. The cut-off value of S NfL for assessing the degree of neuronal impairment was 10.5 ng.L–1. We found a moderate statistically significant correlation between S NfL and CSF Aß42 in the group with movement disorders, without dementia (rs = 0.631; p = 0.016); between S NfL and CSF Aß40 in the group with movement disorder plus dementia (rs = -0.750; p = 0.052); between S NfL and CSF tTau in the control group (rs = 0.689; p = 0.009); and between S NfL and CSF pTau in the control group (rs = 0.749; p = 0.003). The non-parametric Kruskal–Wallis test revealed statistically significant differences between S NfL, CSF NfL, CSF Aß42, CSF tTau, and CSF pTau and diagnosis within groups. The highest kappa coefficients were found between the concentrations of S NfL and CSF NfL (? = 0.480) and between CSF NfL and CSF tTau (? = 0.351). Conclusion: Our results suggested that NfL and tTau in CSF of patients with cognitive decline could be replaced by the less...

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30210 - Clinical neurology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Frontiers in human neuroscience

ISSN

1662-5161

e-ISSN

1662-5161

Svazek periodika

17

Číslo periodika v rámci svazku

article 1284416

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

11

Strana od-do

1-11

Kód UT WoS článku

001131708300001

EID výsledku v databázi Scopus

2-s2.0-85180881475