ABERRANT AMPLIFICATION OF RECEPTOR TYROSIN-KINASES (RTK) INVOLVED IN CELL CYCLE SIGNALING APPEARS TO DETERMINE PROGNOSIS OF GASTRIC CANCER PATIENTS
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F26475821%3A_____%2F14%3A%230000205" target="_blank" >RIV/26475821:_____/14:#0000205 - isvavai.cz</a>
Výsledek na webu
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DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
ABERRANT AMPLIFICATION OF RECEPTOR TYROSIN-KINASES (RTK) INVOLVED IN CELL CYCLE SIGNALING APPEARS TO DETERMINE PROGNOSIS OF GASTRIC CANCER PATIENTS
Popis výsledku v původním jazyce
Poster describeng aberant amplification of receptor tyrosin-kinases. Follow-up colonoscopies were performed on 30 patients. Recurrence adenoma within 3 years was diagnosed in 11 (37%) of cases. 19 patients (63%) had no adenoma presence or the interval ofrecurrence adenoma was longer than 3 years. Somatic mutations were found in 10 patient in the first and 8 patients in the second group, respectively (90% and 42%; p=0.0249). Mutations were observed in 60% (29/48) of patients with advanced adenoma and in28% (8/28) with early adenoma. Conclusion: Follow-up with recommended intervals is the important tool for prevention of colorectal cancer development, especially in an important subgroup of patients susceptible to recurrent adenoma development. The pilot results imply that the chromosomal instability phenotype (CIN), uncovered by genetic testing of the autonomous tissue, may represent the independent factor of such recurrences increased risk.
Název v anglickém jazyce
ABERRANT AMPLIFICATION OF RECEPTOR TYROSIN-KINASES (RTK) INVOLVED IN CELL CYCLE SIGNALING APPEARS TO DETERMINE PROGNOSIS OF GASTRIC CANCER PATIENTS
Popis výsledku anglicky
Poster describeng aberant amplification of receptor tyrosin-kinases. Follow-up colonoscopies were performed on 30 patients. Recurrence adenoma within 3 years was diagnosed in 11 (37%) of cases. 19 patients (63%) had no adenoma presence or the interval ofrecurrence adenoma was longer than 3 years. Somatic mutations were found in 10 patient in the first and 8 patients in the second group, respectively (90% and 42%; p=0.0249). Mutations were observed in 60% (29/48) of patients with advanced adenoma and in28% (8/28) with early adenoma. Conclusion: Follow-up with recommended intervals is the important tool for prevention of colorectal cancer development, especially in an important subgroup of patients susceptible to recurrent adenoma development. The pilot results imply that the chromosomal instability phenotype (CIN), uncovered by genetic testing of the autonomous tissue, may represent the independent factor of such recurrences increased risk.
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
EB - Genetika a molekulární biologie
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/NT13640" target="_blank" >NT13640: Uplatnění panelu molekulárních markerů v klinickém managementu progredujícího karcinomu žaludku</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2014
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů