Neutron Dosimetry at HK-1 beam line of LVR-15 reactor for Biomedical Sample Irradiations

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F26722445%3A_____%2F24%3AN0000138" target="_blank" >RIV/26722445:_____/24:N0000138 - isvavai.cz</a>

Výsledek na webu

<a href="https://eproceedings.epublishing.ekt.gr/index.php/hnps/article/view/6285" target="_blank" >https://eproceedings.epublishing.ekt.gr/index.php/hnps/article/view/6285</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.12681/hnpsanp.6285" target="_blank" >10.12681/hnpsanp.6285</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Neutron Dosimetry at HK-1 beam line of LVR-15 reactor for Biomedical Sample Irradiations

Popis výsledku v původním jazyce

Dosimetric calculations were performed for the interpretation of the results of in vitro irradiation experiments of cell cultures at the HK-1 thermal neutron line of the LVR-15 research reactor in Řež, Czech Republic. Monte Carlo simulations of neutron irradiated well-type vials containing solutions of natGd or natB were carried out to calculate the energy deposition from each particle type produced by thermal neutron capture reactions in 10B and 157Gd for each solution, respectively. Moreover, the geometry of a single cell as target was simulated to predict microdosimetric spectra for different Gd and B solution distributions in the volume surrounding the target cell and calculate neutron fluence to Kerma factors. Although the calculations apply to Gd nuclei, it is assumed that Gd was supplied to the cells in a chelated form to avoid toxicity. Special attention was given to the Auger electrons from Gd. The results of the study support in vitro thermal neutron irradiation experiments aiming to test new boron and gadolinium carriers for neutron capture therapy.

Název v anglickém jazyce

Neutron Dosimetry at HK-1 beam line of LVR-15 reactor for Biomedical Sample Irradiations

Popis výsledku anglicky

Dosimetric calculations were performed for the interpretation of the results of in vitro irradiation experiments of cell cultures at the HK-1 thermal neutron line of the LVR-15 research reactor in Řež, Czech Republic. Monte Carlo simulations of neutron irradiated well-type vials containing solutions of natGd or natB were carried out to calculate the energy deposition from each particle type produced by thermal neutron capture reactions in 10B and 157Gd for each solution, respectively. Moreover, the geometry of a single cell as target was simulated to predict microdosimetric spectra for different Gd and B solution distributions in the volume surrounding the target cell and calculate neutron fluence to Kerma factors. Although the calculations apply to Gd nuclei, it is assumed that Gd was supplied to the cells in a chelated form to avoid toxicity. Special attention was given to the Auger electrons from Gd. The results of the study support in vitro thermal neutron irradiation experiments aiming to test new boron and gadolinium carriers for neutron capture therapy.

Druh

D - Stať ve sborníku

CEP obor

—

OECD FORD obor

10304 - Nuclear physics

Projekt

—

Návaznosti

—

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

HNPS : Advances in Nuclear Physics, vol. 30 (2024)

ISBN

—

ISSN

2654-007X

e-ISSN

2654-0088

Počet stran výsledku

4

Strana od-do

207-210

Název nakladatele

—

Místo vydání

—

Místo konání akce

Athens, Greece

Datum konání akce

29. 9. 2023

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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