Monte Carlo Simulations for Dosimetry and Microdosimetry for Biomedical Sample Irradiations with Thermal Neutron Beams

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F26722445%3A_____%2F24%3AN0000213" target="_blank" >RIV/26722445:_____/24:N0000213 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Monte Carlo Simulations for Dosimetry and Microdosimetry for Biomedical Sample Irradiations with Thermal Neutron Beams

Popis výsledku v původním jazyce

In the framework of the FRINGE project [1] investigating novel agents for Gd neutron capture therapy, neutron irradiations are performed at the Swiss Spallation Neutron Source (SINQ) at Paul Scherrer Institut (PSI), Switzerland and at the LVR-15 reactor at Research Centre Řež, Czech Republic. Cell cultures tagged with different Gd agents are irradiated with neutrons to study their cell killing effectiveness. The aim of the present study is to investigate the dosimetric characteristics of the two facilities for neutron irradiations of cell cultures. Monte Carlo simulations were performed using the MCNP6.1 code to evaluate the absorbed dose, the dose energy distribution, as well as to delineate microdosimetric spectra of protons, heavy particles and electrons for the two neutron beams examined. Such spectra allow for the prediction of the biological response of cells exposed in neutron fields based on response data obtained in gamma-fields. Microdosimetric data were combined with appropriate weighting functions, in order to determine the relative biological effectiveness (RBE) in each case. The present study supports the results of the in vitro cell culture irradiations performed in FRINGE, as well as implements a methodology allowing an estimation of the biological effectiveness of neutron fields with different characteristics. Presented at International Conference Applied Nuclear Physics , 23. 9. 2024 – 27. 9. 2024, Thessaliniki, Greece.

Název v anglickém jazyce

Monte Carlo Simulations for Dosimetry and Microdosimetry for Biomedical Sample Irradiations with Thermal Neutron Beams

Popis výsledku anglicky

In the framework of the FRINGE project [1] investigating novel agents for Gd neutron capture therapy, neutron irradiations are performed at the Swiss Spallation Neutron Source (SINQ) at Paul Scherrer Institut (PSI), Switzerland and at the LVR-15 reactor at Research Centre Řež, Czech Republic. Cell cultures tagged with different Gd agents are irradiated with neutrons to study their cell killing effectiveness. The aim of the present study is to investigate the dosimetric characteristics of the two facilities for neutron irradiations of cell cultures. Monte Carlo simulations were performed using the MCNP6.1 code to evaluate the absorbed dose, the dose energy distribution, as well as to delineate microdosimetric spectra of protons, heavy particles and electrons for the two neutron beams examined. Such spectra allow for the prediction of the biological response of cells exposed in neutron fields based on response data obtained in gamma-fields. Microdosimetric data were combined with appropriate weighting functions, in order to determine the relative biological effectiveness (RBE) in each case. The present study supports the results of the in vitro cell culture irradiations performed in FRINGE, as well as implements a methodology allowing an estimation of the biological effectiveness of neutron fields with different characteristics. Presented at International Conference Applied Nuclear Physics , 23. 9. 2024 – 27. 9. 2024, Thessaliniki, Greece.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

20501 - Materials engineering

Projekt

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Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů