A Dosimetric and Biological Model for Neutron Capture Therapy (NCT) Experiments

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F26722445%3A_____%2F25%3AN0000013" target="_blank" >RIV/26722445:_____/25:N0000013 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0969804325005780" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0969804325005780</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.apradiso.2025.112233" target="_blank" >10.1016/j.apradiso.2025.112233</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A Dosimetric and Biological Model for Neutron Capture Therapy (NCT) Experiments

Popis výsledku v původním jazyce

A hybrid Monte Carlo approach using MCNP in combination with the cell-level code Monte Carlo Damage Simulation (MCDS) is presented to support the design and analysis of experiments for the evaluation of gadolinium (Gd) based agents in neutron capture therapy (NCT). Monoenergetic neutrons (0.025 eV–15 MeV) and polyenergetic neutron beams from NEUTRA, ICON (PSI, Switzerland), and HK1 (LVR-15, Czech Republic) were used to estimate the relative biological effectiveness (RBE) of NCT for the biologically critical endpoint of DNA double strand break (DSB) production relative to 60Co γ-rays. Moreover, microdosimetric spectra of protons, electrons, alpha particles and heavy recoils were determined for the aforementioned neutron beams, to enhance the interpretation of energy deposition in subcellular structrures. The proposed, hybrid model and methodology builds on well-validated dosimetry and biophysical models at different spatial scales to create a versatile and generalized framework to estimate dosimetric parameters and RBE. This approach facilitates comparisons between NCT and low linear energy transfer (LET) radiation alternatives.

Název v anglickém jazyce

A Dosimetric and Biological Model for Neutron Capture Therapy (NCT) Experiments

Popis výsledku anglicky

A hybrid Monte Carlo approach using MCNP in combination with the cell-level code Monte Carlo Damage Simulation (MCDS) is presented to support the design and analysis of experiments for the evaluation of gadolinium (Gd) based agents in neutron capture therapy (NCT). Monoenergetic neutrons (0.025 eV–15 MeV) and polyenergetic neutron beams from NEUTRA, ICON (PSI, Switzerland), and HK1 (LVR-15, Czech Republic) were used to estimate the relative biological effectiveness (RBE) of NCT for the biologically critical endpoint of DNA double strand break (DSB) production relative to 60Co γ-rays. Moreover, microdosimetric spectra of protons, electrons, alpha particles and heavy recoils were determined for the aforementioned neutron beams, to enhance the interpretation of energy deposition in subcellular structrures. The proposed, hybrid model and methodology builds on well-validated dosimetry and biophysical models at different spatial scales to create a versatile and generalized framework to estimate dosimetric parameters and RBE. This approach facilitates comparisons between NCT and low linear energy transfer (LET) radiation alternatives.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10303 - Particles and field physics

Projekt

—

Návaznosti

R - Projekt Ramcoveho programu EK

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Applied Radiation and Isotopes

ISSN

0969-8043

e-ISSN

1872-9800

Svazek periodika

226

Číslo periodika v rámci svazku

December

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

1-7

Kód UT WoS článku

001597077200001

EID výsledku v databázi Scopus

2-s2.0-105018318882