Comprehensive assessment of electrospun scaffolds hemocompatibility

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F27283933%3A_____%2F17%3A00005345" target="_blank" >RIV/27283933:_____/17:00005345 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/46747885:24410/18:00004140 RIV/67985891:_____/18:00482099 RIV/68407700:21220/18:00315051

Výsledek na webu

<a href="https://api.elsevier.com/content/article/eid/1-s2.0-S0928493116307913" target="_blank" >https://api.elsevier.com/content/article/eid/1-s2.0-S0928493116307913</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.msec.2017.05.011" target="_blank" >10.1016/j.msec.2017.05.011</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Comprehensive assessment of electrospun scaffolds hemocompatibility

Popis výsledku v původním jazyce

Biodegradable polyesters, namely polycaprolactone (PCL) and copolymer of polylactide and polycaprolactone (PLCL) were electrospun into various fibrous structures and their hemocompatibility was evaluated in vitro. Firstly, hemolytic effect was evaluated upon incubation with diluted whole blood. The results showed that the degree of hemolysis depended on chemical composition and fibrous morphology. Electrospun polycaprolactone induced slight degree of hemolysis depending on its molecular weight and fibrous morphology; copolymer PLCL did not cause detectable hemolysis. The influence of coagulation pathways was examined by measurement of coagulation times. It was showed that intrinsic coagulation pathway assessed by activated partial thromboplastin time (APTT) was moderately accelerated after incubation with PCL and prolonged after incubation with copolymer PLCL. Extrinsic activation of coagulation tested by prothrombin time (PT) was slightly accelerated after incubation with all tested electrospun samples. Thrombogenicity assessment of fibrous samples revealed high thrombogenic properties of fibrous materials that was comparable to high degree of collagen thrombogenicity. The level of platelet activation was dependent on chemical composition and surface morphology of tested materials.

Název v anglickém jazyce

Comprehensive assessment of electrospun scaffolds hemocompatibility

Popis výsledku anglicky

Biodegradable polyesters, namely polycaprolactone (PCL) and copolymer of polylactide and polycaprolactone (PLCL) were electrospun into various fibrous structures and their hemocompatibility was evaluated in vitro. Firstly, hemolytic effect was evaluated upon incubation with diluted whole blood. The results showed that the degree of hemolysis depended on chemical composition and fibrous morphology. Electrospun polycaprolactone induced slight degree of hemolysis depending on its molecular weight and fibrous morphology; copolymer PLCL did not cause detectable hemolysis. The influence of coagulation pathways was examined by measurement of coagulation times. It was showed that intrinsic coagulation pathway assessed by activated partial thromboplastin time (APTT) was moderately accelerated after incubation with PCL and prolonged after incubation with copolymer PLCL. Extrinsic activation of coagulation tested by prothrombin time (PT) was slightly accelerated after incubation with all tested electrospun samples. Thrombogenicity assessment of fibrous samples revealed high thrombogenic properties of fibrous materials that was comparable to high degree of collagen thrombogenicity. The level of platelet activation was dependent on chemical composition and surface morphology of tested materials.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

30230 - Other clinical medicine subjects

Projekt

<a href="/cs/project/NV15-29241A" target="_blank" >NV15-29241A: Nanovlákenná biodegradabilní maloprůměrová cévní náhrada</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Materials Science and Engineering C

ISSN

0928-4931

e-ISSN

—

Svazek periodika

82

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

6

Strana od-do

330-335

Kód UT WoS článku

—

EID výsledku v databázi Scopus

2-s2.0-85029397377