Implementation of the GOLD 2017 disease classification in a real-life COPD cohort

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F27661989%3A_____%2F18%3AN0000020" target="_blank" >RIV/27661989:_____/18:N0000020 - isvavai.cz</a>

Výsledek na webu

<a href="https://publications.ersnet.org/content/erj/52/suppl62/pa3858" target="_blank" >https://publications.ersnet.org/content/erj/52/suppl62/pa3858</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1183/13993003.congress-2018.PA3858" target="_blank" >10.1183/13993003.congress-2018.PA3858</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Implementation of the GOLD 2017 disease classification in a real-life COPD cohort

Popis výsledku v původním jazyce

Introduction: During the last decade, the GOLD classification of COPD underwent notable evolution. There is limited evidence how the latest classification approach affected the distribution of COPD patients accross A-D groups. Our aim was to assess predictive value of the last 3 GOLD classification systems (I-IV (pre 2011), A-D (2011-2016) and A-D (2017-present)) in relation to long-term mortality of COPD patients from the CMRD cohort. Methods: We used the prospective data of 784 patients from the CMRD cohort (at 4-year follow-up). Kaplan-Meier survival analysis was performed for the 3 above mentioned GOLD classification systems. Results: Application of the GOLD I-IV system showed gradual and significant increase in 4-year mortality across the stages (GOLD II 18.7%, GOLD III 28.5%, GOLD IV 38.7%) (p=0.001). Application of the GOLD A-D system (2011-2016) showed group D being the most populous category with 523 patients (66.7%) and highest rate of 4-year mortality (30%). Group C patients had lower mortality (17.9%) than group B patients (18.7%) (p=0.01). Finally, using the GOLD A-D 2017 classification approach resulted in major shifts of patients accross groups A-D with group B being most abundant (52.5%). Similarly, mortality in group B patients was significantly higher (25%) than in group C (23.1%). Conclusion: Our results show that the current GOLD classification possesses gradual predictive value for long-term mortality. Another important finding is that the adaptation of the 2017 GOLD Update resulted in shift from group D to B of ca 40% of former group D COPD patients. In consequence, this might result in significant treatment reduction (with possible harmful consequences)in a real-life setting.

Název v anglickém jazyce

Implementation of the GOLD 2017 disease classification in a real-life COPD cohort

Popis výsledku anglicky

Introduction: During the last decade, the GOLD classification of COPD underwent notable evolution. There is limited evidence how the latest classification approach affected the distribution of COPD patients accross A-D groups. Our aim was to assess predictive value of the last 3 GOLD classification systems (I-IV (pre 2011), A-D (2011-2016) and A-D (2017-present)) in relation to long-term mortality of COPD patients from the CMRD cohort. Methods: We used the prospective data of 784 patients from the CMRD cohort (at 4-year follow-up). Kaplan-Meier survival analysis was performed for the 3 above mentioned GOLD classification systems. Results: Application of the GOLD I-IV system showed gradual and significant increase in 4-year mortality across the stages (GOLD II 18.7%, GOLD III 28.5%, GOLD IV 38.7%) (p=0.001). Application of the GOLD A-D system (2011-2016) showed group D being the most populous category with 523 patients (66.7%) and highest rate of 4-year mortality (30%). Group C patients had lower mortality (17.9%) than group B patients (18.7%) (p=0.01). Finally, using the GOLD A-D 2017 classification approach resulted in major shifts of patients accross groups A-D with group B being most abundant (52.5%). Similarly, mortality in group B patients was significantly higher (25%) than in group C (23.1%). Conclusion: Our results show that the current GOLD classification possesses gradual predictive value for long-term mortality. Another important finding is that the adaptation of the 2017 GOLD Update resulted in shift from group D to B of ca 40% of former group D COPD patients. In consequence, this might result in significant treatment reduction (with possible harmful consequences)in a real-life setting.

Druh

J_ost - Ostatní články v recenzovaných periodicích

CEP obor

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OECD FORD obor

30203 - Respiratory systems

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Respiratory Journal

ISSN

0903-1936

e-ISSN

1399-3003

Svazek periodika

52

Číslo periodika v rámci svazku

Supplement 62

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

1

Strana od-do

PA3858

Kód UT WoS článku

000455567104496

EID výsledku v databázi Scopus

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