Prognostic Accuracy of Three COPD Classification Systems in Relation to Long-Term Mortality of COPD Patients: A Prospective Multicenter Study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F19%3A73600841" target="_blank" >RIV/61989592:15110/19:73600841 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14110/19:00109670 RIV/00216208:11150/19:10398648 RIV/65269705:_____/19:00070530 RIV/00179906:_____/19:10398648 RIV/00843989:_____/19:E0107800

Výsledek na webu

<a href="https://link.springer.com/article/10.1007/s00408-019-00196-6" target="_blank" >https://link.springer.com/article/10.1007/s00408-019-00196-6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00408-019-00196-6" target="_blank" >10.1007/s00408-019-00196-6</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Prognostic Accuracy of Three COPD Classification Systems in Relation to Long-Term Mortality of COPD Patients: A Prospective Multicenter Study

Popis výsledku v původním jazyce

Recent research showed group B patients express higher mortality compared to group C patients when GOLD A-D grouping is used. We aimed to compare the prognostic accuracy of three GOLD classification systems, I–IV (“pre-2011”), A-D (“2011–2016”) and A-D (“2017–present”) in relation to mortality, exacerbation risk, quality of life (QoL) assessment and specific treatments use in a real-life COPD cohort. We used the data of 720 patients from the Czech Multicenter Research Database of COPD. Four-year mortality and time-to-exacerbation using the GOLD “pre-2011”, “2011–2016” and “2017–present” classification schemes were assessed. Moreover, distribution of specific treatments use and QoL measures were analyzed. The GOLD I-IV classification system showed gradual increase in 4-year mortality across the stages (GOLD II 18.8%, III 28.5%, IV 38.7%) (p = 0.001). Using the A-D “2011–2016” classification scheme, group C patients had lower mortality (16.7%) than group B (18.7%) (p = 0.009). The A-D “2017–present” classification showed higher mortality in group B (25.5%) compared to group C (20%) (p = 0.05). For additional outcomes, the GOLD I–IV scheme showed highest match between the calculated 4-year exacerbation risk and QoL measures and GOLD stage/grouping. In terms of specific treatment distributions, various patterns for each GOLD classification system were observed with best match of GOLD “2017–present” system to the layout of GOLD groups and categories. We conclude the GOLD I–IV classification system had the highest accuracy related to mortality, QoL measures and exacerbation risk prediction, while the A-D “2017–present” scheme was most accurate within severity of symptoms prediction reflected also by more frequent specific treatments use.

Název v anglickém jazyce

Prognostic Accuracy of Three COPD Classification Systems in Relation to Long-Term Mortality of COPD Patients: A Prospective Multicenter Study

Popis výsledku anglicky

Recent research showed group B patients express higher mortality compared to group C patients when GOLD A-D grouping is used. We aimed to compare the prognostic accuracy of three GOLD classification systems, I–IV (“pre-2011”), A-D (“2011–2016”) and A-D (“2017–present”) in relation to mortality, exacerbation risk, quality of life (QoL) assessment and specific treatments use in a real-life COPD cohort. We used the data of 720 patients from the Czech Multicenter Research Database of COPD. Four-year mortality and time-to-exacerbation using the GOLD “pre-2011”, “2011–2016” and “2017–present” classification schemes were assessed. Moreover, distribution of specific treatments use and QoL measures were analyzed. The GOLD I-IV classification system showed gradual increase in 4-year mortality across the stages (GOLD II 18.8%, III 28.5%, IV 38.7%) (p = 0.001). Using the A-D “2011–2016” classification scheme, group C patients had lower mortality (16.7%) than group B (18.7%) (p = 0.009). The A-D “2017–present” classification showed higher mortality in group B (25.5%) compared to group C (20%) (p = 0.05). For additional outcomes, the GOLD I–IV scheme showed highest match between the calculated 4-year exacerbation risk and QoL measures and GOLD stage/grouping. In terms of specific treatment distributions, various patterns for each GOLD classification system were observed with best match of GOLD “2017–present” system to the layout of GOLD groups and categories. We conclude the GOLD I–IV classification system had the highest accuracy related to mortality, QoL measures and exacerbation risk prediction, while the A-D “2017–present” scheme was most accurate within severity of symptoms prediction reflected also by more frequent specific treatments use.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

30203 - Respiratory systems

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

LUNG

ISSN

0341-2040

e-ISSN

—

Svazek periodika

197

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

7

Strana od-do

173-179

Kód UT WoS článku

000466205900009

EID výsledku v databázi Scopus

2-s2.0-85061043758