What is uric acid concentration in urine in patients with uric acid kidney stones?- a case study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F27661989%3A_____%2F25%3A10003005" target="_blank" >RIV/27661989:_____/25:10003005 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/70883521:28150/25:63594759

Výsledek na webu

<a href="https://www.biochemia-medica.com/en/journal/35/3/10.11613/BM.2025.031001" target="_blank" >https://www.biochemia-medica.com/en/journal/35/3/10.11613/BM.2025.031001</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.11613/BM.2025.031001" target="_blank" >10.11613/BM.2025.031001</a>

Jazyk výsledku

angličtina

Název v původním jazyce

What is uric acid concentration in urine in patients with uric acid kidney stones?- a case study

Popis výsledku v původním jazyce

This case report describes a patient with uric acid kidney stones. Alkalization therapy using mainly potassium citrate is the first-choice treatment. When hyperuricosuria &gt; 4 mmol/24 hours is present, xanthine oxidase inhibitors are added. It implies that accurate urine uric acid measurement is of high importance. Uric acid was measured in a 24-hour collection and a second-morning sample. Urine uric acid was measured after sample alkalization to pH &gt; 6.5 and heating to 56 degrees C for 10 minutes, and for educational reasons without sample treatment. The uric acid excretion in the sample without alkalization in the 24-hour collection was 2.436 mmol, after alkalization, the excretion was 4.650 mmol/24 hours. Sample alkalization led to a prescription for xanthine oxidase inhibitor medication that is indicated as the second-line therapy when hyperuricosuria &gt; 4 mmol/24 hours is present. This case study shows how the correct preanalytical phase is essential for medical decision-making.

Název v anglickém jazyce

What is uric acid concentration in urine in patients with uric acid kidney stones?- a case study

Popis výsledku anglicky

This case report describes a patient with uric acid kidney stones. Alkalization therapy using mainly potassium citrate is the first-choice treatment. When hyperuricosuria &gt; 4 mmol/24 hours is present, xanthine oxidase inhibitors are added. It implies that accurate urine uric acid measurement is of high importance. Uric acid was measured in a 24-hour collection and a second-morning sample. Urine uric acid was measured after sample alkalization to pH &gt; 6.5 and heating to 56 degrees C for 10 minutes, and for educational reasons without sample treatment. The uric acid excretion in the sample without alkalization in the 24-hour collection was 2.436 mmol, after alkalization, the excretion was 4.650 mmol/24 hours. Sample alkalization led to a prescription for xanthine oxidase inhibitor medication that is indicated as the second-line therapy when hyperuricosuria &gt; 4 mmol/24 hours is present. This case study shows how the correct preanalytical phase is essential for medical decision-making.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30218 - General and internal medicine

Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biochemia Medica

ISSN

1330-0962

e-ISSN

1846-7482

Svazek periodika

35

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

HR - Chorvatská republika

Počet stran výsledku

5

Strana od-do

nestránkováno

Kód UT WoS článku

001615200300006

EID výsledku v databázi Scopus

2-s2.0-105013687779