Influence of oxygen on the chemical stage of radiobiological mechanism

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F44555601%3A13440%2F16%3A43887664" target="_blank" >RIV/44555601:13440/16:43887664 - isvavai.cz</a>

Výsledek na webu

<a href="http://ac.els-cdn.com/S0969806X16300342/1-s2.0-S0969806X16300342-main.pdf?_tid=e2ffd068-2c7a-11e6-bad4-00000aacb362&acdnat=1465281878_df5b1b8775f8fced7febba823e2b8240" target="_blank" >http://ac.els-cdn.com/S0969806X16300342/1-s2.0-S0969806X16300342-main.pdf?_tid=e2ffd068-2c7a-11e6-bad4-00000aacb362&acdnat=1465281878_df5b1b8775f8fced7febba823e2b8240</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.radphyschem.2016.01.035" target="_blank" >10.1016/j.radphyschem.2016.01.035</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Influence of oxygen on the chemical stage of radiobiological mechanism

Popis výsledku v původním jazyce

The simulation of the chemical stage of radiobiological mechanism may be very helpful in studying the radiobiological effect of ionizing radiation when the water radical clusters formed by the densely ionizing ends of primary or secondary charged particle may form DSBs damaging DNA molecules in living cells. It is possible to study not only the efficiency of individual radicals but also the influence of other species or radiomodifiers (mainly oxygen) being present in water medium during irradiation. The mathematical model based on Continuous Petri nets (proposed by us recently) will be described. It makes it possible to analyze two main processes running at the same time: chemical radical reactions and the diffusion of radical clusters formed during energy transfer. One may study the time change of radical concentrations due to the chemical reactions running during diffusion process. Some orientation results concerning the efficiency of individual radicals in DSB formation (in the case of Co60 radiation) will be presented; the influence of oxygen present in water medium during irradiation will be shown, too.

Název v anglickém jazyce

Influence of oxygen on the chemical stage of radiobiological mechanism

Popis výsledku anglicky

The simulation of the chemical stage of radiobiological mechanism may be very helpful in studying the radiobiological effect of ionizing radiation when the water radical clusters formed by the densely ionizing ends of primary or secondary charged particle may form DSBs damaging DNA molecules in living cells. It is possible to study not only the efficiency of individual radicals but also the influence of other species or radiomodifiers (mainly oxygen) being present in water medium during irradiation. The mathematical model based on Continuous Petri nets (proposed by us recently) will be described. It makes it possible to analyze two main processes running at the same time: chemical radical reactions and the diffusion of radical clusters formed during energy transfer. One may study the time change of radical concentrations due to the chemical reactions running during diffusion process. Some orientation results concerning the efficiency of individual radicals in DSB formation (in the case of Co60 radiation) will be presented; the influence of oxygen present in water medium during irradiation will be shown, too.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

BO - Biofyzika

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Radiation Physics And Chemistry

ISSN

0969-806X

e-ISSN

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Svazek periodika

2016

Číslo periodika v rámci svazku

124

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

116-123

Kód UT WoS článku

000375736200021

EID výsledku v databázi Scopus

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