Filtration of DNA Nucleotide Gene Expression Profiles in the Systems of Biological Objects Clustering

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F44555601%3A13440%2F16%3A43887686" target="_blank" >RIV/44555601:13440/16:43887686 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.scipress.com/IFSL.8.1" target="_blank" >https://www.scipress.com/IFSL.8.1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.18052/www.scipress.com/IFSL.8.1" target="_blank" >10.18052/www.scipress.com/IFSL.8.1</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Filtration of DNA Nucleotide Gene Expression Profiles in the Systems of Biological Objects Clustering

Popis výsledku v původním jazyce

Researches on an optimization of the filtration process of DNA nucleotides gene expression profiles are presented in the article. The data of lung cancer patients E-GEOD-68571 of Array Express database were used as experimental data. Filtration was carried out under the terms of the expression detecting of corresponding gene, herewith the variance of gene expression, the absolute value of expression and the Shannon entropy were used as criteria. The value of thresholding coefficient was estimated on the basis of average proximity measure of objects within the homogenous group and between groups. 470 columns were removed in the process of data filtering, and the matrix dimension of the test data has changed from (96x7129) to (96x6659). Estimation of the quality of information processing was performed by the comparative analysis of the clustering results of processed and unprocessed data.

Název v anglickém jazyce

Filtration of DNA Nucleotide Gene Expression Profiles in the Systems of Biological Objects Clustering

Popis výsledku anglicky

Researches on an optimization of the filtration process of DNA nucleotides gene expression profiles are presented in the article. The data of lung cancer patients E-GEOD-68571 of Array Express database were used as experimental data. Filtration was carried out under the terms of the expression detecting of corresponding gene, herewith the variance of gene expression, the absolute value of expression and the Shannon entropy were used as criteria. The value of thresholding coefficient was estimated on the basis of average proximity measure of objects within the homogenous group and between groups. 470 columns were removed in the process of data filtering, and the matrix dimension of the test data has changed from (96x7129) to (96x6659). Estimation of the quality of information processing was performed by the comparative analysis of the clustering results of processed and unprocessed data.

Druh

J_ost - Ostatní články v recenzovaných periodicích

CEP obor

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OECD FORD obor

10201 - Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Frontier Science Letters

ISSN

2349-4484

e-ISSN

—

Svazek periodika

2016

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

8

Strana od-do

1-8

Kód UT WoS článku

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EID výsledku v databázi Scopus

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