Preparation of PSEBS membranes bearing (S)-(MINUS SIGN )-methylbenzylamine as chiral selector

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F44555601%3A13440%2F20%3A43894889" target="_blank" >RIV/44555601:13440/20:43894889 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0014305719311930#" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0014305719311930#</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.eurpolymj.2019.109381" target="_blank" >10.1016/j.eurpolymj.2019.109381</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Preparation of PSEBS membranes bearing (S)-(MINUS SIGN )-methylbenzylamine as chiral selector

Popis výsledku v původním jazyce

Nowadays, there is a strong need for replacement of racemates by enantiomerically pure drugs. Enantioseparation on polymer membranes seems to be one of the promising and economically feasible technologies for this purpose. As a material for membrane construction, linear polymer molecules bearing covalently bonded chiral selectors are very promising according to recent reports. A membrane formed from chloromethylated polystyrene-block-poly(ethylene-ran-butylene)-block-polystyrene (PSEBS) was cast and subsequently functionalized with a chiral selector (S)-(MINUS SIGN )-?-methylbenzylamine. In preferential sorption experiments with racemic tryptophan and ibuprofen, the prepared membrane exhibited a higher affinity to l-tryptophan and (R)-(MINUS SIGN )-ibuprofen than to corresponding enantiomers. The significant change in peak ratio from 48:52 to 60:40 (d-tryptophan:l-tryptophan) was observed. This indicates the high potential of the covalently bonded (S)-(MINUS SIGN )-?-methylbenzylamine selector for the fabrication of membranes selective towards chiral acids and ampholytes.

Název v anglickém jazyce

Preparation of PSEBS membranes bearing (S)-(MINUS SIGN )-methylbenzylamine as chiral selector

Popis výsledku anglicky

Nowadays, there is a strong need for replacement of racemates by enantiomerically pure drugs. Enantioseparation on polymer membranes seems to be one of the promising and economically feasible technologies for this purpose. As a material for membrane construction, linear polymer molecules bearing covalently bonded chiral selectors are very promising according to recent reports. A membrane formed from chloromethylated polystyrene-block-poly(ethylene-ran-butylene)-block-polystyrene (PSEBS) was cast and subsequently functionalized with a chiral selector (S)-(MINUS SIGN )-?-methylbenzylamine. In preferential sorption experiments with racemic tryptophan and ibuprofen, the prepared membrane exhibited a higher affinity to l-tryptophan and (R)-(MINUS SIGN )-ibuprofen than to corresponding enantiomers. The significant change in peak ratio from 48:52 to 60:40 (d-tryptophan:l-tryptophan) was observed. This indicates the high potential of the covalently bonded (S)-(MINUS SIGN )-?-methylbenzylamine selector for the fabrication of membranes selective towards chiral acids and ampholytes.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10403 - Physical chemistry

Projekt

<a href="/cs/project/GA17-00089S" target="_blank" >GA17-00089S: Separace racemických směsí membránovými procesy</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Polymer Journal

ISSN

0014-3057

e-ISSN

—

Svazek periodika

2020

Číslo periodika v rámci svazku

122

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

6

Strana od-do

"nestrankovano"

Kód UT WoS článku

000509784900049

EID výsledku v databázi Scopus

2-s2.0-85076056630