Metalloenzyme-inspired approach to the design and applications of phosphatase-mimetic nanozymes. Bridging the inorganic and organic worlds

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F44555601%3A13520%2F24%3A43898985" target="_blank" >RIV/44555601:13520/24:43898985 - isvavai.cz</a>

Výsledek na webu

<a href="https://pubs.rsc.org/en/content/articlelanding/2024/en/d4en00144c" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2024/en/d4en00144c</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/d4en00144c" target="_blank" >10.1039/d4en00144c</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Metalloenzyme-inspired approach to the design and applications of phosphatase-mimetic nanozymes. Bridging the inorganic and organic worlds

Popis výsledku v původním jazyce

Nanozymes were introduced approximately 15 years ago as inorganic materials capable of mimicking the catalytic abilities of natural (protein-based) enzymes. While the catalytic efficiency of nanozymes typically does not match that of enzymes, their research gains special attention due to their potential advantages over conventional enzymes, particularly their higher resistance to adverse conditions. This article focuses on the utilization of cerium oxide for the catalytic acceleration of non-redox reactions (e.g., dephosphorylation). It elucidates certain analogies between the functioning of conventional enzymes (metalloenzymes) and the nanozymatic activity of ceria, and the distinctions in the mechanisms of action between the two catalyst types. The unique catalytic (enzymatic) ability of cerium oxide is predetermined by the fine interplay between surface reactivity (associated with surface defects) and structural integrity (simplicity and stability of the subsurface crystalline structure). Limitations associated with the less flexible nature of cerium oxide are discussed, together with strategies to overcome them, which are based on the new concept of dynamic active sites. Possible generalizations to other metal oxide-based nanozymes are briefly mentioned.

Název v anglickém jazyce

Metalloenzyme-inspired approach to the design and applications of phosphatase-mimetic nanozymes. Bridging the inorganic and organic worlds

Popis výsledku anglicky

Nanozymes were introduced approximately 15 years ago as inorganic materials capable of mimicking the catalytic abilities of natural (protein-based) enzymes. While the catalytic efficiency of nanozymes typically does not match that of enzymes, their research gains special attention due to their potential advantages over conventional enzymes, particularly their higher resistance to adverse conditions. This article focuses on the utilization of cerium oxide for the catalytic acceleration of non-redox reactions (e.g., dephosphorylation). It elucidates certain analogies between the functioning of conventional enzymes (metalloenzymes) and the nanozymatic activity of ceria, and the distinctions in the mechanisms of action between the two catalyst types. The unique catalytic (enzymatic) ability of cerium oxide is predetermined by the fine interplay between surface reactivity (associated with surface defects) and structural integrity (simplicity and stability of the subsurface crystalline structure). Limitations associated with the less flexible nature of cerium oxide are discussed, together with strategies to overcome them, which are based on the new concept of dynamic active sites. Possible generalizations to other metal oxide-based nanozymes are briefly mentioned.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

21001 - Nano-materials (production and properties)

Projekt

<a href="/cs/project/LM2015073" target="_blank" >LM2015073: Nanomateriály a nanotechnologie pro ochranu životního prostředí a udržitelnou budoucnost</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Environmental Science-Nano

ISSN

2051-8153

e-ISSN

2051-8161

Svazek periodika

11

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

17

Strana od-do

3268-3285

Kód UT WoS článku

001251311300001

EID výsledku v databázi Scopus

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