Can cerium oxide serve as a phosphodiesterase-mimetic nanozyme?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388980%3A_____%2F19%3A00518330" target="_blank" >RIV/61388980:_____/19:00518330 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/29372259:_____/19:N0000007 RIV/44555601:13440/19:43894853 RIV/44555601:13520/19:43894853

Výsledek na webu

<a href="https://pubs.rsc.org/en/content/articlelanding/2019/EN/C9EN00815B#!divAbstract" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2019/EN/C9EN00815B#!divAbstract</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/c9en00815b" target="_blank" >10.1039/c9en00815b</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Can cerium oxide serve as a phosphodiesterase-mimetic nanozyme?

Popis výsledku v původním jazyce

The enzyme-mimicking activities of nanocrystalline cerium oxide (nanoceria) are well recognized, and its ability to accelerate the dephosphorylation of simple organophosphates and energetically rich biomolecules such as adenosine triphosphate (ATP) has previously been proven. Here, we hypothesized that cerium oxide may also be effective in the cleavage of more-resistant phosphoester bonds, namely, those in 3′,5′-cyclic adenosine monophosphate (cAMP), which mimics the 3′-5′ phosphodiester bonds in nucleic acids well. The nanoceria-Accelerated dephosphorylation of cAMP proceeds on the time scale of 102-103 min (compared with 106 years in the absence of cerium oxide) and is only slightly affected by pH. The dephosphorylation activity is highly specific to cerium oxide, as it was not observed with oxides of neighbouring lanthanides (La2O3, Pr6O11, and Nd2O3) or with other metal oxides. The nanoceria also decomposed the organophosphate pesticides parathion and paraoxon methyl and the chemical warfare agents soman and VX. A new model was proposed to describe the activation of dephosphorylation reactions in the presence of (nano)ceria. An unusual phosphatase-mimetic activity resulted from an interplay between properly arranged Ce3+ and Ce4+ cations and cerium-Activated hydroxyl groups. The special structural motifs responsible for the phosphatase-mimetic activity are dynamically created and regenerated on the surface of cerium oxide thanks to the Ce3+/Ce4+ switching ability of cerium cations and a flexible oxygen-conducting structure of cerium oxide.

Název v anglickém jazyce

Can cerium oxide serve as a phosphodiesterase-mimetic nanozyme?

Popis výsledku anglicky

The enzyme-mimicking activities of nanocrystalline cerium oxide (nanoceria) are well recognized, and its ability to accelerate the dephosphorylation of simple organophosphates and energetically rich biomolecules such as adenosine triphosphate (ATP) has previously been proven. Here, we hypothesized that cerium oxide may also be effective in the cleavage of more-resistant phosphoester bonds, namely, those in 3′,5′-cyclic adenosine monophosphate (cAMP), which mimics the 3′-5′ phosphodiester bonds in nucleic acids well. The nanoceria-Accelerated dephosphorylation of cAMP proceeds on the time scale of 102-103 min (compared with 106 years in the absence of cerium oxide) and is only slightly affected by pH. The dephosphorylation activity is highly specific to cerium oxide, as it was not observed with oxides of neighbouring lanthanides (La2O3, Pr6O11, and Nd2O3) or with other metal oxides. The nanoceria also decomposed the organophosphate pesticides parathion and paraoxon methyl and the chemical warfare agents soman and VX. A new model was proposed to describe the activation of dephosphorylation reactions in the presence of (nano)ceria. An unusual phosphatase-mimetic activity resulted from an interplay between properly arranged Ce3+ and Ce4+ cations and cerium-Activated hydroxyl groups. The special structural motifs responsible for the phosphatase-mimetic activity are dynamically created and regenerated on the surface of cerium oxide thanks to the Ce3+/Ce4+ switching ability of cerium cations and a flexible oxygen-conducting structure of cerium oxide.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10402 - Inorganic and nuclear chemistry

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Environmental Science-Nano

ISSN

2051-8153

e-ISSN

—

Svazek periodika

6

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

15

Strana od-do

3684-3698

Kód UT WoS článku

000501324000012

EID výsledku v databázi Scopus

2-s2.0-85076214161