Nanocrystalline cerium oxide prepared from a carbonate precursor and its ability to breakdown biologically relevant organophosphates

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388980%3A_____%2F17%3A00475963" target="_blank" >RIV/61388980:_____/17:00475963 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/44555601:13440/17:43892867 RIV/44555601:13520/17:43892867 RIV/61989592:15310/17:73584076

Výsledek na webu

<a href="http://dx.doi.org/10.1039/c7en00119c" target="_blank" >http://dx.doi.org/10.1039/c7en00119c</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/c7en00119c" target="_blank" >10.1039/c7en00119c</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Nanocrystalline cerium oxide prepared from a carbonate precursor and its ability to breakdown biologically relevant organophosphates

Popis výsledku v původním jazyce

The unusual ability of cerium oxide to cleave phosphoester bonds under relatively mild (ambient) conditions was demonstrated using thiamine pyrophosphate (TPP) and nicotinamide adenine dinucleotide (NAD) as model compounds. This phosphatase-mimetic ability can be exploited in biology or medicine, e.g., for protein design, however, it represents a potential threat to vital systems in living organisms, such as the phosphate backbone of DNA and RNA. The ability of cerium oxide to promote the cleavage of the bridging pyrophosphate group in the NAD molecule was examined for the first time, it was shown that the cleavage products differ markedly from the commonly observed products of enzymatic or non-enzymatic hydrolysis of NAD. This ability is highly specific for cerium oxide, it was not observed to a comparable extent with any of the other tested metal oxides (La2O3, Nd2O3, Pr6O11, TiO2, manganese oxide and several iron oxides). The phosphatase-mimetic ability stems from the unique properties of cerium cations and may be related to measurable and, to some extent, adjustable characteristics, such as crystallinity, surface area, Ce3+/Ce4+ ratio or the content of surface functional groups. The in-house prepared nanocrystalline cerium oxide exhibited a markedly higher phosphatase-mimetic ability than the commercial nanoceria. The interactions of the cerium oxide nanoparticles with TPP and NAD were also examined with the aid of molecular dynamics simulations.

Název v anglickém jazyce

Nanocrystalline cerium oxide prepared from a carbonate precursor and its ability to breakdown biologically relevant organophosphates

Popis výsledku anglicky

The unusual ability of cerium oxide to cleave phosphoester bonds under relatively mild (ambient) conditions was demonstrated using thiamine pyrophosphate (TPP) and nicotinamide adenine dinucleotide (NAD) as model compounds. This phosphatase-mimetic ability can be exploited in biology or medicine, e.g., for protein design, however, it represents a potential threat to vital systems in living organisms, such as the phosphate backbone of DNA and RNA. The ability of cerium oxide to promote the cleavage of the bridging pyrophosphate group in the NAD molecule was examined for the first time, it was shown that the cleavage products differ markedly from the commonly observed products of enzymatic or non-enzymatic hydrolysis of NAD. This ability is highly specific for cerium oxide, it was not observed to a comparable extent with any of the other tested metal oxides (La2O3, Nd2O3, Pr6O11, TiO2, manganese oxide and several iron oxides). The phosphatase-mimetic ability stems from the unique properties of cerium cations and may be related to measurable and, to some extent, adjustable characteristics, such as crystallinity, surface area, Ce3+/Ce4+ ratio or the content of surface functional groups. The in-house prepared nanocrystalline cerium oxide exhibited a markedly higher phosphatase-mimetic ability than the commercial nanoceria. The interactions of the cerium oxide nanoparticles with TPP and NAD were also examined with the aid of molecular dynamics simulations.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10402 - Inorganic and nuclear chemistry

Projekt

<a href="/cs/project/LM2015073" target="_blank" >LM2015073: Nanomateriály a nanotechnologie pro ochranu životního prostředí a udržitelnou budoucnost</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Environmental Science-Nano

ISSN

2051-8153

e-ISSN

—

Svazek periodika

4

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

11

Strana od-do

1283-1293

Kód UT WoS článku

000403554500005

EID výsledku v databázi Scopus

2-s2.0-85021665460