Different inhibition of acetylcholinesterase in selected parts of the rat brain following intoxication with VX and Russian VX

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24210%2F09%3A%230001095" target="_blank" >RIV/46747885:24210/09:#0001095 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60162694:G44__/09:00002113 RIV/00216208:11150/09:00208803

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Different inhibition of acetylcholinesterase in selected parts of the rat brain following intoxication with VX and Russian VX

Popis výsledku v původním jazyce

Differences between acetylcholinesterase (AChE) inhibition in the brain structures following VX and RVX exposure are not known as well as information on the possible correlation of biochemical and histochemical methods detecting AChE activity. Therefore,inhibition of AChE in different brain parts detected by histochemical and biochemical techniques was compared in rats intoxicated with VX and RVX. AChE activities in defined brain regions 30 min after treating rats with VX and Russian VX intramuscularly(1.0 x LD50) were determined by using biochemical and histochemical methods. AChE inhibition was less expressed for RVX, in comparison with VX. Frontal cortex and pontomedullar areas containing ncl. reticularis has been found as the most sensitive areasfor the action of VX. For RVX, these structures were determined to be frontal cortex, dorsal septum, and hippocampus, respectively.

Název v anglickém jazyce

Different inhibition of acetylcholinesterase in selected parts of the rat brain following intoxication with VX and Russian VX

Popis výsledku anglicky

Differences between acetylcholinesterase (AChE) inhibition in the brain structures following VX and RVX exposure are not known as well as information on the possible correlation of biochemical and histochemical methods detecting AChE activity. Therefore,inhibition of AChE in different brain parts detected by histochemical and biochemical techniques was compared in rats intoxicated with VX and RVX. AChE activities in defined brain regions 30 min after treating rats with VX and Russian VX intramuscularly(1.0 x LD50) were determined by using biochemical and histochemical methods. AChE inhibition was less expressed for RVX, in comparison with VX. Frontal cortex and pontomedullar areas containing ncl. reticularis has been found as the most sensitive areasfor the action of VX. For RVX, these structures were determined to be frontal cortex, dorsal septum, and hippocampus, respectively.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EA - Morfologické obory a cytologie

OECD FORD obor

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Projekt

<a href="/cs/project/OPUOFVZ200603" target="_blank" >OPUOFVZ200603: INTOX - Nový způsob profylaxe, dekontaminace, diagnostiky a terapie při intoxikaci NPL a yperity</a><br>

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

DRUG AND CHEMICAL TOXICOLOGY

ISSN

0148-0545

e-ISSN

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Svazek periodika

32

Číslo periodika v rámci svazku

2009

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

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Kód UT WoS článku

000266590400001

EID výsledku v databázi Scopus

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