Silk fibroin/hydroxyapatite scaffolds combining lyophilised sponge and nanofibers for bone regeneration

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24210%2F18%3A00008528" target="_blank" >RIV/46747885:24210/18:00008528 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/46747885:24620/18:00008528

Výsledek na webu

<a href="https://i-cors.org/event/european-orthopaedic-research-society-2018-galway-ireland/" target="_blank" >https://i-cors.org/event/european-orthopaedic-research-society-2018-galway-ireland/</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Silk fibroin/hydroxyapatite scaffolds combining lyophilised sponge and nanofibers for bone regeneration

Popis výsledku v původním jazyce

Silk fibroin is a natural fibrous protein derived from Bombyx mori, which is well-studied for tissue engineering and regenerative applications. Silk can be fabricated to different forms including hydrogels, films or sponges. Combination of both lyophilized sponge 3D structure and nanofibers mimics conditions inside the bone and provides mechanical support for the bone cells. Biocompatibility of silk fibroin and hydroxyapatite provides possibility for osteogenic cells to proliferate and gradually repair bone defect without scarf formation, vascularization or significant effect to patient immune system. Influence of different amounts of hydroxyapatite addition to biocompatibility to human cell lines was tested under in vitro conditions. We also studied mechanical properties, degradation rate and morphological changes in dependence on the different conditions of material stabilization and sterilization. In conclusion, the bicomponent scaffolds prepared in this study show very promising properties for bone tissue engineering. (poster presentation)

Název v anglickém jazyce

Silk fibroin/hydroxyapatite scaffolds combining lyophilised sponge and nanofibers for bone regeneration

Popis výsledku anglicky

Silk fibroin is a natural fibrous protein derived from Bombyx mori, which is well-studied for tissue engineering and regenerative applications. Silk can be fabricated to different forms including hydrogels, films or sponges. Combination of both lyophilized sponge 3D structure and nanofibers mimics conditions inside the bone and provides mechanical support for the bone cells. Biocompatibility of silk fibroin and hydroxyapatite provides possibility for osteogenic cells to proliferate and gradually repair bone defect without scarf formation, vascularization or significant effect to patient immune system. Influence of different amounts of hydroxyapatite addition to biocompatibility to human cell lines was tested under in vitro conditions. We also studied mechanical properties, degradation rate and morphological changes in dependence on the different conditions of material stabilization and sterilization. In conclusion, the bicomponent scaffolds prepared in this study show very promising properties for bone tissue engineering. (poster presentation)

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30404 - Biomaterials (as related to medical implants, devices, sensors)

Projekt

<a href="/cs/project/TH03020281" target="_blank" >TH03020281: Biodegradabilní materiály na bázi silk fibroinu pro použití v ortopedii</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

C - Předmět řešení projektu podléhá obchodnímu tajemství (§ 504 Občanského zákoníku), ale název projektu, cíle projektu a u ukončeného nebo zastaveného projektu zhodnocení výsledku řešení projektu (údaje P03, P04, P15, P19, P29, PN8) dodané do CEP, jsou upraveny tak, aby byly zveřejnitelné.