Nanofibrous patches for cardiac drug delivery

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24220%2F16%3A00008524" target="_blank" >RIV/46747885:24220/16:00008524 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/46747885:24620/16:00008524

Výsledek na webu

<a href="https://www.confer.cz/nanocon/2016/read/509-nanofibrous-patches-for-cardiac-drug-delivery.pdf" target="_blank" >https://www.confer.cz/nanocon/2016/read/509-nanofibrous-patches-for-cardiac-drug-delivery.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Nanofibrous patches for cardiac drug delivery

Popis výsledku v původním jazyce

Potential application of nanofibers in drug delivery has attracted a huge attention recently highlighting their properties including increased surface reactivity, high specific surface and improved drug bioavailability. Cardiac regenerative therapy, whereby pro-regenerative cells, drugs or growth factors are administered to myocardium has demonstrated significant potential in post-operative therapy. One of the main conditions applied on drug delivery system materials are cardiac biocompatibility, tolerability, treatment efficacy. Our objective in this study was to develop a nanofibrous patch with a short degradation time for cardiac drug delivery and evaluate its properties relevant for the application site. Silk fibroin based nanofibres were manufactured from Bombyx mori raw cocoons by degum procedure, ionic liquid dissolution and subsequent needle-less electrospinning. The electrospun nanofibres were crosslinked by alcohol dehydration. Stabilized and unstabilized nanofibrous patches were characterized in terms of morphology, chemical composition and degradation kinetics. The main objective was focused on cardiac cytotoxic effect of nanofibres and its evaluation on H9C2 rat myoblastic cell line.

Název v anglickém jazyce

Nanofibrous patches for cardiac drug delivery

Popis výsledku anglicky

Potential application of nanofibers in drug delivery has attracted a huge attention recently highlighting their properties including increased surface reactivity, high specific surface and improved drug bioavailability. Cardiac regenerative therapy, whereby pro-regenerative cells, drugs or growth factors are administered to myocardium has demonstrated significant potential in post-operative therapy. One of the main conditions applied on drug delivery system materials are cardiac biocompatibility, tolerability, treatment efficacy. Our objective in this study was to develop a nanofibrous patch with a short degradation time for cardiac drug delivery and evaluate its properties relevant for the application site. Silk fibroin based nanofibres were manufactured from Bombyx mori raw cocoons by degum procedure, ionic liquid dissolution and subsequent needle-less electrospinning. The electrospun nanofibres were crosslinked by alcohol dehydration. Stabilized and unstabilized nanofibrous patches were characterized in terms of morphology, chemical composition and degradation kinetics. The main objective was focused on cardiac cytotoxic effect of nanofibres and its evaluation on H9C2 rat myoblastic cell line.

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

20602 - Medical laboratory technology (including laboratory samples analysis; diagnostic technologies) (Biomaterials to be 2.9 [physical characteristics of living material as related to medical implants, devices, sensors])

Projekt

<a href="/cs/project/LO1201" target="_blank" >LO1201: ROZVOJ ÚSTAVU PRO NANOMATERIÁLY, POKROČILÉ TECHNOLOGIE A INOVACE TECHNICKÉ UNIVERZITY V LIBERCI</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

NANOCON 2016 - Conference Proceedings, 8th International Conference on Nanomaterials - Research and Application

ISBN

978-808729471-0

ISSN

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e-ISSN

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Počet stran výsledku

6

Strana od-do

478-483

Název nakladatele

TANGER Ltd.

Místo vydání

Brno

Místo konání akce

Brno

Datum konání akce

1. 1. 2016

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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