Crayfish Hemocyanin Promotes the Proliferation and Osteogenic Differentiation of Human Mesenchymal Stem Cells on Chitin Scaffolds

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24220%2F20%3A00008522" target="_blank" >RIV/46747885:24220/20:00008522 - isvavai.cz</a>

Výsledek na webu

<a href="https://pubmed.ncbi.nlm.nih.gov/31755232/" target="_blank" >https://pubmed.ncbi.nlm.nih.gov/31755232/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/jbm.a.36849" target="_blank" >10.1002/jbm.a.36849</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Crayfish Hemocyanin Promotes the Proliferation and Osteogenic Differentiation of Human Mesenchymal Stem Cells on Chitin Scaffolds

Popis výsledku v původním jazyce

In this study, we developed and investigated hemocyanin-modified chitin- calcium-mineral complexes as composite materials for bone regeneration. In particular the focus was put on their ability to bind or release calcium ions and thus influence osteoblastogenesis in vitro. Incorporation of crustacean (crayfish) hemocyanin in these scaffolds was performed, since it plays a significant role in intermittent calcium mineral storage and release. Surprisingly, even hemocyanin alone exhibits enhanced proliferation and osteogenic differentiation. Furthermore, the hemocyanin-modification significantly increased human mesenchymal stem cell adhesion, proliferation and osteogenic differentiation. Under addition of CaCO3 to the scaffolds the hemocyanin-modification led to highest proliferation of hMSC.

Název v anglickém jazyce

Crayfish Hemocyanin Promotes the Proliferation and Osteogenic Differentiation of Human Mesenchymal Stem Cells on Chitin Scaffolds

Popis výsledku anglicky

In this study, we developed and investigated hemocyanin-modified chitin- calcium-mineral complexes as composite materials for bone regeneration. In particular the focus was put on their ability to bind or release calcium ions and thus influence osteoblastogenesis in vitro. Incorporation of crustacean (crayfish) hemocyanin in these scaffolds was performed, since it plays a significant role in intermittent calcium mineral storage and release. Surprisingly, even hemocyanin alone exhibits enhanced proliferation and osteogenic differentiation. Furthermore, the hemocyanin-modification significantly increased human mesenchymal stem cell adhesion, proliferation and osteogenic differentiation. Under addition of CaCO3 to the scaffolds the hemocyanin-modification led to highest proliferation of hMSC.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20903 - Bioproducts (products that are manufactured using biological material as feedstock) biomaterials, bioplastics, biofuels, bioderived bulk and fine chemicals, bio-derived novel materials

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Biomedical Materials Research - Part A

ISSN

1549-3296

e-ISSN

—

Svazek periodika

108

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

15

Strana od-do

694-708

Kód UT WoS článku

000501192900001

EID výsledku v databázi Scopus

2-s2.0-85076357517