Phosphorus-Containing Polymeric Zwitterion: A Pioneering Bioresponsive Probe for P-31-Magnetic Resonance Imaging

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24220%2F22%3A00009524" target="_blank" >RIV/46747885:24220/22:00009524 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/46747885:24530/22:00009524 RIV/00023001:_____/22:00082636 RIV/00216208:11110/22:10442799 RIV/00216224:14740/22:00128771

Výsledek na webu

<a href="https://pubmed.ncbi.nlm.nih.gov/35246950/" target="_blank" >https://pubmed.ncbi.nlm.nih.gov/35246950/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/mabi.202100523" target="_blank" >10.1002/mabi.202100523</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Phosphorus-Containing Polymeric Zwitterion: A Pioneering Bioresponsive Probe for P-31-Magnetic Resonance Imaging

Popis výsledku v původním jazyce

31 P-magnetic resonance (MR) is an important diagnostic technique currently used for tissue metabolites assessing, but it also has great potential for visualizing the internal body structures. However, due to the low physiological level of phosphorus-containing biomolecules, precise imaging requires the administration of an exogenous probe. Herein, this work describes the synthesis and MR characterization of a pioneering metal-free 31 P-MR probe based on phosphorus-containing polymeric zwitterion. The developed probe (pTMPC) is a well-defined water-soluble macromolecule characterized by a high content of naturally rare phosphorothioate groups providing a high-intensity 31 P-MR signal clearly distinguishable from biological background both in vitro and in vitro. In addition, pTMPC can serve as a sensitive 31 P-MR sensor of pathological conditions in vivo because it undergoes oxidation-induced structural changes in the presence of reactive oxygen species (ROS). Add to this the favorable 1 H and 31 P T1 /T2 relaxation times and biocompatibility, pTMPC represents a conceptually new diagnostic, whose discovery opens up new possibilities in the field of 31 P-MR spectroscopy and imaging.

Název v anglickém jazyce

Phosphorus-Containing Polymeric Zwitterion: A Pioneering Bioresponsive Probe for P-31-Magnetic Resonance Imaging

Popis výsledku anglicky

31 P-magnetic resonance (MR) is an important diagnostic technique currently used for tissue metabolites assessing, but it also has great potential for visualizing the internal body structures. However, due to the low physiological level of phosphorus-containing biomolecules, precise imaging requires the administration of an exogenous probe. Herein, this work describes the synthesis and MR characterization of a pioneering metal-free 31 P-MR probe based on phosphorus-containing polymeric zwitterion. The developed probe (pTMPC) is a well-defined water-soluble macromolecule characterized by a high content of naturally rare phosphorothioate groups providing a high-intensity 31 P-MR signal clearly distinguishable from biological background both in vitro and in vitro. In addition, pTMPC can serve as a sensitive 31 P-MR sensor of pathological conditions in vivo because it undergoes oxidation-induced structural changes in the presence of reactive oxygen species (ROS). Add to this the favorable 1 H and 31 P T1 /T2 relaxation times and biocompatibility, pTMPC represents a conceptually new diagnostic, whose discovery opens up new possibilities in the field of 31 P-MR spectroscopy and imaging.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

<a href="/cs/project/NU20-08-00095" target="_blank" >NU20-08-00095: Nové paradigma pro funkční kontrastní látky pro 31P zobrazování magnetickou rezonancí</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2022

Kód důvěrnosti údajů

C - Předmět řešení projektu podléhá obchodnímu tajemství (§ 504 Občanského zákoníku), ale název projektu, cíle projektu a u ukončeného nebo zastaveného projektu zhodnocení výsledku řešení projektu (údaje P03, P04, P15, P19, P29, PN8) dodané do CEP, jsou upraveny tak, aby byly zveřejnitelné.

Název periodika

Macromolecular Bioscience

ISSN

1616-5187

e-ISSN

—

Svazek periodika

22

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

10

Strana od-do

—

Kód UT WoS článku

000766947400001

EID výsledku v databázi Scopus

2-s2.0-85126066378