Sulfate radical-mediated degradation of vancomycin: Kinetics, mechanism, and toxicity evaluation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24220%2F25%3A00013629" target="_blank" >RIV/46747885:24220/25:00013629 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/46747885:24620/25:00013629

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S1383586625035324" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1383586625035324</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.seppur.2025.134935" target="_blank" >10.1016/j.seppur.2025.134935</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Sulfate radical-mediated degradation of vancomycin: Kinetics, mechanism, and toxicity evaluation

Popis výsledku v původním jazyce

Sulfate radical-based process (SRP) is a class of remediation technologies that may be more effective under certain circumstances than conventional oxidation methods. This study investigated a thermally (30–60 °C) activated persulfate to degrade vancomycin (VAN), an organic micropollutant in water. The bimolecular rate constant between sulfate radical and VAN was determined by competition kinetics to be 3.4 × 108 M−1 s−1. The acidic and alkaline pH and common natural water constituents [HCO3–, Cl– and humic acid (HA)] influence the VAN oxidation by the sulfate radical (however, VAN at a concentration of 6.9 µM was always completely degraded in less than one hour). The scavenging test showed that the sulfate radicals (SO4) were responsible for VAN degradation; however, the observed increase in degradation in the presence of HCO3− suggests the involvement of an additional radical species, CO3. An oxidation by-product (acetylated VAN also without CH3N fraction) was predicted by the quantum chemical calculations and verified by HPLC-qTOF-HRMS analysis. Furthermore, it was proven by Algaltoxkit F toxicity test that the by-product was much less toxic for Selenastrum capricornutum microalgae than VAN. It may be concluded that the reaction of sulfate radicals with VAN is fast (3.4 × 108 M−1 s−1), and due to the high selectivity of sulfate radicals to electron-rich moieties, it can be efficiently applied for VAN removal in various environmental matrices.

Název v anglickém jazyce

Sulfate radical-mediated degradation of vancomycin: Kinetics, mechanism, and toxicity evaluation

Popis výsledku anglicky

Sulfate radical-based process (SRP) is a class of remediation technologies that may be more effective under certain circumstances than conventional oxidation methods. This study investigated a thermally (30–60 °C) activated persulfate to degrade vancomycin (VAN), an organic micropollutant in water. The bimolecular rate constant between sulfate radical and VAN was determined by competition kinetics to be 3.4 × 108 M−1 s−1. The acidic and alkaline pH and common natural water constituents [HCO3–, Cl– and humic acid (HA)] influence the VAN oxidation by the sulfate radical (however, VAN at a concentration of 6.9 µM was always completely degraded in less than one hour). The scavenging test showed that the sulfate radicals (SO4) were responsible for VAN degradation; however, the observed increase in degradation in the presence of HCO3− suggests the involvement of an additional radical species, CO3. An oxidation by-product (acetylated VAN also without CH3N fraction) was predicted by the quantum chemical calculations and verified by HPLC-qTOF-HRMS analysis. Furthermore, it was proven by Algaltoxkit F toxicity test that the by-product was much less toxic for Selenastrum capricornutum microalgae than VAN. It may be concluded that the reaction of sulfate radicals with VAN is fast (3.4 × 108 M−1 s−1), and due to the high selectivity of sulfate radicals to electron-rich moieties, it can be efficiently applied for VAN removal in various environmental matrices.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20401 - Chemical engineering (plants, products)

Projekt

—

Návaznosti

—

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Separation and Purification Technology>

ISSN

1383-5866

e-ISSN

—

Svazek periodika

379

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

11

Strana od-do

—

Kód UT WoS článku

001568018900001

EID výsledku v databázi Scopus

2-s2.0-105015143776