Photodegradation of Atorvastatin under Light Conditions Relevant to Natural Waters and Photoproducts Toxicity Assessment

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F21%3A43904321" target="_blank" >RIV/60076658:12310/21:43904321 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.scirp.org/pdf/ojapps_2021042315182428.pdf" target="_blank" >https://www.scirp.org/pdf/ojapps_2021042315182428.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4236/ojapps.2021.104035" target="_blank" >10.4236/ojapps.2021.104035</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Photodegradation of Atorvastatin under Light Conditions Relevant to Natural Waters and Photoproducts Toxicity Assessment

Popis výsledku v původním jazyce

Atorvastatin, widely prescribed hypolipidemic drug, undergoes rapid, probably self-sensitised, degradation (less than 20% left after 25-minute irradiation) if irradiated by wavelengths 300 - 350 nm in aqueous solution. When ferric ions are added to the reaction mixture, the degradation follows first order kinetics with a rate constant of 0.130 min−1 . Photochemical degradation may thus represent a significant way of environmental transformation of this pharmaceutical. Toxicity testing of atorvastatin and atorvastatin photoproducts performed on the water plant Lemna minor revealed that atorvastatin itself exhibited no observable toxic effect measured as leaf area growth inhibition, while the photoproducts showed a significant toxicity to the plant, which shows the extreme importance of investigating not only toxicity of drugs themselves on aquatic organisms but also effects of their transformation products.

Název v anglickém jazyce

Photodegradation of Atorvastatin under Light Conditions Relevant to Natural Waters and Photoproducts Toxicity Assessment

Popis výsledku anglicky

Atorvastatin, widely prescribed hypolipidemic drug, undergoes rapid, probably self-sensitised, degradation (less than 20% left after 25-minute irradiation) if irradiated by wavelengths 300 - 350 nm in aqueous solution. When ferric ions are added to the reaction mixture, the degradation follows first order kinetics with a rate constant of 0.130 min−1 . Photochemical degradation may thus represent a significant way of environmental transformation of this pharmaceutical. Toxicity testing of atorvastatin and atorvastatin photoproducts performed on the water plant Lemna minor revealed that atorvastatin itself exhibited no observable toxic effect measured as leaf area growth inhibition, while the photoproducts showed a significant toxicity to the plant, which shows the extreme importance of investigating not only toxicity of drugs themselves on aquatic organisms but also effects of their transformation products.

Druh

J_ost - Ostatní články v recenzovaných periodicích

CEP obor

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OECD FORD obor

10511 - Environmental sciences (social aspects to be 5.7)

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Open Journal of Applied Sciences

ISSN

2165-3917

e-ISSN

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Svazek periodika

11

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

CN - Čínská lidová republika

Počet stran výsledku

11

Strana od-do

489-499

Kód UT WoS článku

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EID výsledku v databázi Scopus

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