Effects of atorvastatin and its photoproducts on three trophic levels of the aquatic food web

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F25%3A00639285" target="_blank" >RIV/61388971:_____/25:00639285 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60076658:12310/25:43909924 RIV/62156489:43210/25:43926863 RIV/62157124:16270/25:43882858

Výsledek na webu

<a href="https://link.springer.com/article/10.1007/s13762-025-06551-w" target="_blank" >https://link.springer.com/article/10.1007/s13762-025-06551-w</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s13762-025-06551-w" target="_blank" >10.1007/s13762-025-06551-w</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effects of atorvastatin and its photoproducts on three trophic levels of the aquatic food web

Popis výsledku v původním jazyce

Atorvastatin (ATV) photodegradation with radiation relevant to the shortest solar radiation wavelengths reaching the Earth's surface was studied. Fourteen products of atorvastatin photodegradation (P-ATV) were identified by HPLC-HRMS/MS, chemical structures were proposed for twelve of them. The suggested structures include decarboxylated, dehydrated ATV, ether-like structures and phenanthrene-like byproducts. Toxicity assays revealed that exposure to ATV had a greater negative effect on the growth of the green algae Desmodesmus subspicatus than the exposure to P-ATV (IC20 values 140 mu g/l and 475 mu g/l, resp.). The opposite trend was observed with Daphnia magna where P-ATV was 12 times more toxic than ATV with LC50 values of 3.25 mg/l and 38.5 mg/l, resp.). Long-term exposure to environmental concentrations showed that P-ATV significantly lowered the number of juveniles of D. magna, while ATV had no effect. Neither ATV nor P-ATV affected the interclutch period or the number of clutches. The higher toxicity of P-ATV was observed also in the 96-h test with Danio rerio embryos (the determined LC50 values for ATV and P-ATV 5.56 mg/l and 2.74 mg/l, resp.). Both groups of embryos of D. rerio (exposed to ATV or P-ATV) showed malformations such as heart and yolk sac oedema with the more pronounced effect in P-ATV. The novelty of the study is in a significant contribution to the understanding of the photochemical degradation of atorvastatin under UV light conditions relevant to surface waters together with the demonstration of deleterious effects of photoproduct mixture on the selected aquatic organisms of different trophic levels.

Název v anglickém jazyce

Effects of atorvastatin and its photoproducts on three trophic levels of the aquatic food web

Popis výsledku anglicky

Atorvastatin (ATV) photodegradation with radiation relevant to the shortest solar radiation wavelengths reaching the Earth's surface was studied. Fourteen products of atorvastatin photodegradation (P-ATV) were identified by HPLC-HRMS/MS, chemical structures were proposed for twelve of them. The suggested structures include decarboxylated, dehydrated ATV, ether-like structures and phenanthrene-like byproducts. Toxicity assays revealed that exposure to ATV had a greater negative effect on the growth of the green algae Desmodesmus subspicatus than the exposure to P-ATV (IC20 values 140 mu g/l and 475 mu g/l, resp.). The opposite trend was observed with Daphnia magna where P-ATV was 12 times more toxic than ATV with LC50 values of 3.25 mg/l and 38.5 mg/l, resp.). Long-term exposure to environmental concentrations showed that P-ATV significantly lowered the number of juveniles of D. magna, while ATV had no effect. Neither ATV nor P-ATV affected the interclutch period or the number of clutches. The higher toxicity of P-ATV was observed also in the 96-h test with Danio rerio embryos (the determined LC50 values for ATV and P-ATV 5.56 mg/l and 2.74 mg/l, resp.). Both groups of embryos of D. rerio (exposed to ATV or P-ATV) showed malformations such as heart and yolk sac oedema with the more pronounced effect in P-ATV. The novelty of the study is in a significant contribution to the understanding of the photochemical degradation of atorvastatin under UV light conditions relevant to surface waters together with the demonstration of deleterious effects of photoproduct mixture on the selected aquatic organisms of different trophic levels.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10511 - Environmental sciences (social aspects to be 5.7)

Projekt

<a href="/cs/project/EF16_019%2F0000869" target="_blank" >EF16_019/0000869: Udržitelná produkce zdravých ryb v různých akvakulturních systémech - PROFISH</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Environmental Science and Technology

ISSN

1735-1472

e-ISSN

1735-2630

Svazek periodika

22

Číslo periodika v rámci svazku

14

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

16

Strana od-do

14293-14308

Kód UT WoS článku

001498492200001

EID výsledku v databázi Scopus

2-s2.0-105006825136