Identification of the photoproducts of the antidiabetic drug metformin and the different impact of metformin compared to its photoproducts mixture on aquatic organisms

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F25%3A43910128" target="_blank" >RIV/60076658:12310/25:43910128 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62156489:43210/25:43927709

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S1382668925002406?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1382668925002406?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.etap.2025.104865" target="_blank" >10.1016/j.etap.2025.104865</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Identification of the photoproducts of the antidiabetic drug metformin and the different impact of metformin compared to its photoproducts mixture on aquatic organisms

Popis výsledku v původním jazyce

Photochemical degradation of the antidiabetic drug metformin in the presence of a quinone sensitiser was investigated under environmentally relevant UV light. Degradation products were identified using UHPLC-QTOF. The effects of the resulting photoproduct mixture and metformin itself (50-100 mu g l-1) were assessed on four aquatic species representing different trophic levels: Desmodesmus subspicatus, Lemna minor, Daphnia magna and Danio rerio embryos. The photoproduct mixture caused growth inhibition in photosynthesising organisms, reproductive disruption in Daphnia, developmental malformations in fish embryos, and significant changes in oxidative stress markers. This study provides the first evidence that photochemically generated transformation products of metformin are significantly more toxic than the parent compound, even at environmentally relevant concentrations. These findings highlight the importance of including not only parent pharmaceuticals but also their photoproducts in environmental risk assessments, as the latter may pose a greater ecological hazard in surface waters.

Název v anglickém jazyce

Identification of the photoproducts of the antidiabetic drug metformin and the different impact of metformin compared to its photoproducts mixture on aquatic organisms

Popis výsledku anglicky

Photochemical degradation of the antidiabetic drug metformin in the presence of a quinone sensitiser was investigated under environmentally relevant UV light. Degradation products were identified using UHPLC-QTOF. The effects of the resulting photoproduct mixture and metformin itself (50-100 mu g l-1) were assessed on four aquatic species representing different trophic levels: Desmodesmus subspicatus, Lemna minor, Daphnia magna and Danio rerio embryos. The photoproduct mixture caused growth inhibition in photosynthesising organisms, reproductive disruption in Daphnia, developmental malformations in fish embryos, and significant changes in oxidative stress markers. This study provides the first evidence that photochemically generated transformation products of metformin are significantly more toxic than the parent compound, even at environmentally relevant concentrations. These findings highlight the importance of including not only parent pharmaceuticals but also their photoproducts in environmental risk assessments, as the latter may pose a greater ecological hazard in surface waters.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10406 - Analytical chemistry

Projekt

<a href="/cs/project/EF16_019%2F0000869" target="_blank" >EF16_019/0000869: Udržitelná produkce zdravých ryb v různých akvakulturních systémech - PROFISH</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Environmental Toxicology and Pharmacology

ISSN

1382-6689

e-ISSN

1872-7077

Svazek periodika

120

Číslo periodika v rámci svazku

DEC 2025

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

13

Strana od-do

nestránkováno

Kód UT WoS článku

001619668300001

EID výsledku v databázi Scopus

2-s2.0-105021868927