New Aligned Microfibers for Tissue Engineering

Kód výsledku v IS VaVaI

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Nalezeny alternativní kódy

RIV/46747885:24620/15:00000649

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

New Aligned Microfibers for Tissue Engineering

Popis výsledku v původním jazyce

The present work deals with preparation and subsequent modification of aligned polycaprolactone microfibers made by new semiautomatic drawing technique. This advanced scaffold for tissue engineering combines 3D architecture, large surface area-to-volume ratio, alterable conductivity which closely imitates native extracellular matrix and actively modulating cell functions. New synthetic approach has been chosen for derivatization of aligned polymer fibers, which lack any surface functional groups for immobilization of biomolecules, grow factors or specific amino acid sequences. To overcome this drawback the thin conductive polypyrrole layer was applied on the polycaprolactone fibers by chemical oxidative polymerization from the solution. Thus, in the one simple synthetic step we can modify original fibers with various functional groups presented in the β-position of the pyrrole. Our future goal is to functionalize microfibrous surface with cyclodextrin units using highly efficient copper free click reaction. Finally we gain an aligned microfibrous scaffold covered by immobilized cyclodextrin macrocycles that allow inclusion of proteins during cell cultivation. These nonbonding interactions are relatively weak but the cumulative effect makes them efficient in the complexation of various neutral or ionic molecules. Moreover better environment for cell adhesion and proliferation is being provided.

Název v anglickém jazyce

New Aligned Microfibers for Tissue Engineering

Popis výsledku anglicky

The present work deals with preparation and subsequent modification of aligned polycaprolactone microfibers made by new semiautomatic drawing technique. This advanced scaffold for tissue engineering combines 3D architecture, large surface area-to-volume ratio, alterable conductivity which closely imitates native extracellular matrix and actively modulating cell functions. New synthetic approach has been chosen for derivatization of aligned polymer fibers, which lack any surface functional groups for immobilization of biomolecules, grow factors or specific amino acid sequences. To overcome this drawback the thin conductive polypyrrole layer was applied on the polycaprolactone fibers by chemical oxidative polymerization from the solution. Thus, in the one simple synthetic step we can modify original fibers with various functional groups presented in the β-position of the pyrrole. Our future goal is to functionalize microfibrous surface with cyclodextrin units using highly efficient copper free click reaction. Finally we gain an aligned microfibrous scaffold covered by immobilized cyclodextrin macrocycles that allow inclusion of proteins during cell cultivation. These nonbonding interactions are relatively weak but the cumulative effect makes them efficient in the complexation of various neutral or ionic molecules. Moreover better environment for cell adhesion and proliferation is being provided.

Druh

D - Stať ve sborníku

CEP obor

CC - Organická chemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Nanocon 2015: 7th International Conference on Nanomaterials - Research and Application

ISBN

978-80-87294-63-5

ISSN

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e-ISSN

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Počet stran výsledku

5

Strana od-do

399-403

Název nakladatele

TANGER Ltd.

Místo vydání

Ostrava

Místo konání akce

Brno

Datum konání akce

1. 1. 2015

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

000374708800070