Functionalized aligned conductive microfibers for application in tissue engineering

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24620%2F16%3A00003646" target="_blank" >RIV/46747885:24620/16:00003646 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/46747885:24410/16:00003646 RIV/46747885:24220/16:00003646

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Functionalized aligned conductive microfibers for application in tissue engineering

Popis výsledku v původním jazyce

Microfibrous scaffolds mimic the features of the native extracellular matrix, which in turn directs numerous aspects of cellular organization and survival. Microfibrous constructs have been used extensively as potential tissue engineering platforms. It is generally hypothesized that a close imitation of the extracellular matrix by microfibers will provide environmental or physical cues to cells.[1]Classically, electrically conducting materials and fibrous scaffolds have been studied separately. However, electrically conducting fibers recently drew attention as tissue engineering scaffolds.[2] They contain both microfibrous features and electrical activity and they are valuable in actively modulating cell functions. Among the conductive polymers for biological applications, polypyrrole (PPy) is the most thoroughly investigated one.[3]In order to extend possibilities of tissue engineering on conductive surfaces it is necessary to modify them with suitable derivatives. Our research is focused on the synthesis of cyclodextrin (CD) modified PPy derivatives. CDs are cyclic oligosaccharides well-known for the ability to include various guests in their cavity in water environment. The CD-PPy covered microfibers thus open the way for versatile conductive material which can bind on its surface biomolecules enhancing cell adhesion, proliferation, activity or possessing other desired features (Fig. 1)

Název v anglickém jazyce

Functionalized aligned conductive microfibers for application in tissue engineering

Popis výsledku anglicky

Microfibrous scaffolds mimic the features of the native extracellular matrix, which in turn directs numerous aspects of cellular organization and survival. Microfibrous constructs have been used extensively as potential tissue engineering platforms. It is generally hypothesized that a close imitation of the extracellular matrix by microfibers will provide environmental or physical cues to cells.[1]Classically, electrically conducting materials and fibrous scaffolds have been studied separately. However, electrically conducting fibers recently drew attention as tissue engineering scaffolds.[2] They contain both microfibrous features and electrical activity and they are valuable in actively modulating cell functions. Among the conductive polymers for biological applications, polypyrrole (PPy) is the most thoroughly investigated one.[3]In order to extend possibilities of tissue engineering on conductive surfaces it is necessary to modify them with suitable derivatives. Our research is focused on the synthesis of cyclodextrin (CD) modified PPy derivatives. CDs are cyclic oligosaccharides well-known for the ability to include various guests in their cavity in water environment. The CD-PPy covered microfibers thus open the way for versatile conductive material which can bind on its surface biomolecules enhancing cell adhesion, proliferation, activity or possessing other desired features (Fig. 1)

Druh

O - Ostatní výsledky

CEP obor

JI - Kompositní materiály

OECD FORD obor

—

Projekt

<a href="/cs/project/GJ16-02316Y" target="_blank" >GJ16-02316Y: Orientovaná vodivá nanovlákna pro tkáňové inženýrství</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů