Novel double-layered planar scaffold combining electrospun PCL fibers and PVA hydrogels with high shape integrity and water stability

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24410%2F20%3A00006987" target="_blank" >RIV/46747885:24410/20:00006987 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/46747885:24510/20:00006987

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0167577X19319135" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0167577X19319135</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.matlet.2019.127281" target="_blank" >10.1016/j.matlet.2019.127281</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Novel double-layered planar scaffold combining electrospun PCL fibers and PVA hydrogels with high shape integrity and water stability

Popis výsledku v původním jazyce

Novel double-layered materials with different properties of each side were prepared via needleless electrospinning and compared in terms of morphology, wettability, adhesion and proliferation of mouse fibroblasts. The materials consist of hydrophilic poly(vinyl alcohol) fibers with low (PVA_L) or high (PVA_H) degree of hydrolysis, and hydrophobic poly(ε-caprolactone) (PCL) fibrous layer. Although the PVA_L fibers were fully dissolved following a water exposure, the shape of the scaffold was maintained due to water stable PCL layer. Exposing PVA_H based fibrous layer to water created a hydrogel-like structure with shape defined by the PCL layer. According to the MTT assay, the mouse fibroblasts seeded on the scaffold exhibited the greatest proliferative activity on the PCL fibers. These double-layered scaffolds with different features on each side are very promising for many novel medical applications such as wound dressing or abdominal adhesion prevention. Article in Materials Letters (Volume 263). Funding received from SGS project Reg. No. 21311.

Název v anglickém jazyce

Novel double-layered planar scaffold combining electrospun PCL fibers and PVA hydrogels with high shape integrity and water stability

Popis výsledku anglicky

Novel double-layered materials with different properties of each side were prepared via needleless electrospinning and compared in terms of morphology, wettability, adhesion and proliferation of mouse fibroblasts. The materials consist of hydrophilic poly(vinyl alcohol) fibers with low (PVA_L) or high (PVA_H) degree of hydrolysis, and hydrophobic poly(ε-caprolactone) (PCL) fibrous layer. Although the PVA_L fibers were fully dissolved following a water exposure, the shape of the scaffold was maintained due to water stable PCL layer. Exposing PVA_H based fibrous layer to water created a hydrogel-like structure with shape defined by the PCL layer. According to the MTT assay, the mouse fibroblasts seeded on the scaffold exhibited the greatest proliferative activity on the PCL fibers. These double-layered scaffolds with different features on each side are very promising for many novel medical applications such as wound dressing or abdominal adhesion prevention. Article in Materials Letters (Volume 263). Funding received from SGS project Reg. No. 21311.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

21001 - Nano-materials (production and properties)

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Materials Letters

ISSN

0167-577X

e-ISSN

—

Svazek periodika

263

Číslo periodika v rámci svazku

March

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

4

Strana od-do

—

Kód UT WoS článku

000513952500073

EID výsledku v databázi Scopus

2-s2.0-85077276366