Electrospun Hpmc/peo-blend Orodispersible Films: How Slight Batch Differences Affect the Crucial Mechanical Properties

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24410%2F23%3A00011812" target="_blank" >RIV/46747885:24410/23:00011812 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/46747885:24510/23:00011812

Výsledek na webu

<a href="https://link.springer.com/article/10.1007/s10570-023-05137-4" target="_blank" >https://link.springer.com/article/10.1007/s10570-023-05137-4</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10570-023-05137-4" target="_blank" >10.1007/s10570-023-05137-4</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Electrospun Hpmc/peo-blend Orodispersible Films: How Slight Batch Differences Affect the Crucial Mechanical Properties

Popis výsledku v původním jazyce

Orodispersible films comprise a promising dosage form with a wide range of advantages compared to conventional formulations. The electrospinning process can significantly enhance the relevant characteristics of orodispersible films, e.g., the dissolution rate and the ease of administration. This study involved the use of two types of hydroxypropyl methylcelluloses of low molecular weight obtained from three different manufacturers as the matrix. The SEM, FTIR, RAMAN, and DSC analyses revealed comparable values for all the fabricated materials. However, the mechanical properties of the fibers differed significantly, with electrospun Methocel E5/PEO proving to be particularly brittle. This is probably caused by the different arrangements of substituted methoxy- and hydroxypropyl groups of studied HPMCs. It is hoped that this paper will serve as an example of the extent to which slight differences between HPMC powder batches can dramatically alter the key properties of electrospun orodispersible films.

Název v anglickém jazyce

Electrospun Hpmc/peo-blend Orodispersible Films: How Slight Batch Differences Affect the Crucial Mechanical Properties

Popis výsledku anglicky

Orodispersible films comprise a promising dosage form with a wide range of advantages compared to conventional formulations. The electrospinning process can significantly enhance the relevant characteristics of orodispersible films, e.g., the dissolution rate and the ease of administration. This study involved the use of two types of hydroxypropyl methylcelluloses of low molecular weight obtained from three different manufacturers as the matrix. The SEM, FTIR, RAMAN, and DSC analyses revealed comparable values for all the fabricated materials. However, the mechanical properties of the fibers differed significantly, with electrospun Methocel E5/PEO proving to be particularly brittle. This is probably caused by the different arrangements of substituted methoxy- and hydroxypropyl groups of studied HPMCs. It is hoped that this paper will serve as an example of the extent to which slight differences between HPMC powder batches can dramatically alter the key properties of electrospun orodispersible films.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10404 - Polymer science

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cellulose

ISSN

0969-0239

e-ISSN

—

Svazek periodika

30

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

15

Strana od-do

4527-4541

Kód UT WoS článku

000962656300001

EID výsledku v databázi Scopus

2-s2.0-85151397662