Hemostatic Gelatin-Alginate Hydrogels Modified with Humic Acids and Impregnated with Aminocaproic Acid

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24620%2F24%3A00012450" target="_blank" >RIV/46747885:24620/24:00012450 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.lifescienceglobal.com/pms/index.php/jrups/article/view/9690/5049" target="_blank" >https://www.lifescienceglobal.com/pms/index.php/jrups/article/view/9690/5049</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.6000/1929-5995.2024.13.05" target="_blank" >10.6000/1929-5995.2024.13.05</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Hemostatic Gelatin-Alginate Hydrogels Modified with Humic Acids and Impregnated with Aminocaproic Acid

Popis výsledku v původním jazyce

The work is devoted to the development of safe and biocompatible multicomponent gelatin-alginate hydrogels modified with humic acids (HA) and impregnated with the antifibrinolytic agent aminocaproic acid (АА).These hydrogels are designed to be effective hemostatic materials with anti-inflammatory properties and the ability to deliver in less than 30 seconds to deep and hidden areas of hemorrhages. Studies of the crystal structure by X-ray diffraction analysis and non-covalent interactions of molecules by Fourier transform infrared spectroscopy of the developed hemostatic gelatin-alginate hydrogels modified with bactericidal and anti-inflammatory humic acids made it possible to identify the optimal concentrations of HA from 2.5 wt.%. up to 5 wt.%. At such concentrations of HA, gelatin-alginate hydrogels have a semicrystalline structure. Due to non-covalent bonds between polymer chains, they are thermo-responsive with a gel-sol transition temperature of about 37 °C. Impregnation of these hydrogels with aminocaproic acid led to an almost threefold increase in their swelling, which facilitated the dissolution of AA in the hydrogels and its subsequent delivery to the wound. Experiments simulating the transmembrane transport of aminocaproic acid from the developed gelatin-alginate hydrogels confirmed their ability to rapidly deliver up to 494± 3 mg of AA from 5 ml of hydrogel to the wound.

Název v anglickém jazyce

Hemostatic Gelatin-Alginate Hydrogels Modified with Humic Acids and Impregnated with Aminocaproic Acid

Popis výsledku anglicky

The work is devoted to the development of safe and biocompatible multicomponent gelatin-alginate hydrogels modified with humic acids (HA) and impregnated with the antifibrinolytic agent aminocaproic acid (АА).These hydrogels are designed to be effective hemostatic materials with anti-inflammatory properties and the ability to deliver in less than 30 seconds to deep and hidden areas of hemorrhages. Studies of the crystal structure by X-ray diffraction analysis and non-covalent interactions of molecules by Fourier transform infrared spectroscopy of the developed hemostatic gelatin-alginate hydrogels modified with bactericidal and anti-inflammatory humic acids made it possible to identify the optimal concentrations of HA from 2.5 wt.%. up to 5 wt.%. At such concentrations of HA, gelatin-alginate hydrogels have a semicrystalline structure. Due to non-covalent bonds between polymer chains, they are thermo-responsive with a gel-sol transition temperature of about 37 °C. Impregnation of these hydrogels with aminocaproic acid led to an almost threefold increase in their swelling, which facilitated the dissolution of AA in the hydrogels and its subsequent delivery to the wound. Experiments simulating the transmembrane transport of aminocaproic acid from the developed gelatin-alginate hydrogels confirmed their ability to rapidly deliver up to 494± 3 mg of AA from 5 ml of hydrogel to the wound.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

20500 - Materials engineering

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Research Updates in Polymer Science

ISSN

1929-5995

e-ISSN

—

Svazek periodika

13

Číslo periodika v rámci svazku

February

Stát vydavatele periodika

CA - Kanada

Počet stran výsledku

11

Strana od-do

34-44

Kód UT WoS článku

—

EID výsledku v databázi Scopus

2-s2.0-85201663507