Hemostatic Ability of Thermosensitive Biologically Active Gelatin-Alginate Hydrogels Modified with Humic Acids and Impregnated with Aminocaproic Acid

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24620%2F24%3A00012568" target="_blank" >RIV/46747885:24620/24:00012568 - isvavai.cz</a>

Výsledek na webu

<a href="https://lifescienceglobal.com/pms/index.php/jrups/article/view/9845" target="_blank" >https://lifescienceglobal.com/pms/index.php/jrups/article/view/9845</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.6000/1929-5995.2024.13.16" target="_blank" >10.6000/1929-5995.2024.13.16</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Hemostatic Ability of Thermosensitive Biologically Active Gelatin-Alginate Hydrogels Modified with Humic Acids and Impregnated with Aminocaproic Acid

Popis výsledku v původním jazyce

The article studies the hemostatic ability of thermosensitive biopolymer hydrogels containing 14% by weight of gelatin and 6.4% by weight of sodium alginate, impregnated with a hemostatic agent aminocaproic acid ~0.2 g/ml, with the addition of humic acids with antioxidant, antibacterial, fungicidal and anti-inflammatory properties.Modification of hydrogels with humic acids slightly increases viscosity, but maintains the gel-sol transition temperature close to the physiological temperature of about 37 °C, which allows them to melt on human skin or inside a wound, ensuring the delivery of aminocaproic acid. SEM images showed that the developed hydrogels have a layered internal morphology, which is improved due to better swelling of the hydrogels contained humic acids, which promotes the dissolution of aminocaproic acid inside the hydrogels and its subsequent rapid delivery to the bleeding site when applying a hydrogel dressing.It has been experimentally established that the concentration of humic acids in hydrogels of no more than 5 wt.% promotes blood clotting due to the entry of aminocaproic acid into it from the hydrogels.The aminocaproic acid delivered at physiological temperature from these hydrogels can shorten the blood clotting time to the lower limit of the normal clotting time range. The clotting time of the hydrogel with 5 wt.% humic acid is only 95 s, which confirms its particularly effective hemostatic ability.

Název v anglickém jazyce

Hemostatic Ability of Thermosensitive Biologically Active Gelatin-Alginate Hydrogels Modified with Humic Acids and Impregnated with Aminocaproic Acid

Popis výsledku anglicky

The article studies the hemostatic ability of thermosensitive biopolymer hydrogels containing 14% by weight of gelatin and 6.4% by weight of sodium alginate, impregnated with a hemostatic agent aminocaproic acid ~0.2 g/ml, with the addition of humic acids with antioxidant, antibacterial, fungicidal and anti-inflammatory properties.Modification of hydrogels with humic acids slightly increases viscosity, but maintains the gel-sol transition temperature close to the physiological temperature of about 37 °C, which allows them to melt on human skin or inside a wound, ensuring the delivery of aminocaproic acid. SEM images showed that the developed hydrogels have a layered internal morphology, which is improved due to better swelling of the hydrogels contained humic acids, which promotes the dissolution of aminocaproic acid inside the hydrogels and its subsequent rapid delivery to the bleeding site when applying a hydrogel dressing.It has been experimentally established that the concentration of humic acids in hydrogels of no more than 5 wt.% promotes blood clotting due to the entry of aminocaproic acid into it from the hydrogels.The aminocaproic acid delivered at physiological temperature from these hydrogels can shorten the blood clotting time to the lower limit of the normal clotting time range. The clotting time of the hydrogel with 5 wt.% humic acid is only 95 s, which confirms its particularly effective hemostatic ability.

Druh

J_SC - Článek v periodiku v databázi SCOPUS

CEP obor

—

OECD FORD obor

20500 - Materials engineering

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Research Updates in Polymer Science

ISSN

1929-5995

e-ISSN

—

Svazek periodika

13

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

CA - Kanada

Počet stran výsledku

6

Strana od-do

155-160

Kód UT WoS článku

—

EID výsledku v databázi Scopus

2-s2.0-85207965415