A Perspective on the Potential Impact of Microplastics and Nanoplastics on the Human Central Nervous System

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24620%2F25%3A00013038" target="_blank" >RIV/46747885:24620/25:00013038 - isvavai.cz</a>

Výsledek na webu

<a href="https://pubs.rsc.org/en/content/articlelanding/2025/en/d4en01017e" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2025/en/d4en01017e</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/d4en01017e" target="_blank" >10.1039/d4en01017e</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A Perspective on the Potential Impact of Microplastics and Nanoplastics on the Human Central Nervous System

Popis výsledku v původním jazyce

Humans are constantly exposed to microplastics and nanoplastics (MNPs). Although significant gaps remain in our understanding of their adverse effects on human health, it is increasingly evident that MNPs can penetrate physiological barriers and accumulate in various locations within the human body. Analytical limitations in tracking and measuring nanoplastics in physiological media may persist for several years before we can accurately detect these particles in the human body and establish a clear link between exposure to them and associated hazards. In addition to the few studies that have emerged recently, our knowledge of chemicals with properties similar to those of MNPs, as well as other types of nanomaterials, suggests that MNPs may cross the blood-brain barrier (BBB) and potentially induce damage to the human central nervous system. Here, we provide an overview of the limited number of studies available on this topic and present a perspective on the potential pathways through which MNPs may penetrate the BBB. We also discuss the main mechanisms by which MNPs could potentially impact the central nervous system (CNS), with a focus on neurodegenerative diseases such as Alzheimer‘s disease (AD), Parkinson‘s disease (PD), multiple sclerosis (MS), and amyotrophic lateral sclerosis (ALS). This information could contribute to the development of tailored studies exploring the negative effects of MNPs on the CNS.

Název v anglickém jazyce

A Perspective on the Potential Impact of Microplastics and Nanoplastics on the Human Central Nervous System

Popis výsledku anglicky

Humans are constantly exposed to microplastics and nanoplastics (MNPs). Although significant gaps remain in our understanding of their adverse effects on human health, it is increasingly evident that MNPs can penetrate physiological barriers and accumulate in various locations within the human body. Analytical limitations in tracking and measuring nanoplastics in physiological media may persist for several years before we can accurately detect these particles in the human body and establish a clear link between exposure to them and associated hazards. In addition to the few studies that have emerged recently, our knowledge of chemicals with properties similar to those of MNPs, as well as other types of nanomaterials, suggests that MNPs may cross the blood-brain barrier (BBB) and potentially induce damage to the human central nervous system. Here, we provide an overview of the limited number of studies available on this topic and present a perspective on the potential pathways through which MNPs may penetrate the BBB. We also discuss the main mechanisms by which MNPs could potentially impact the central nervous system (CNS), with a focus on neurodegenerative diseases such as Alzheimer‘s disease (AD), Parkinson‘s disease (PD), multiple sclerosis (MS), and amyotrophic lateral sclerosis (ALS). This information could contribute to the development of tailored studies exploring the negative effects of MNPs on the CNS.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10400 - Chemical sciences

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ENVIRONMENTAL SCIENCE-NANO>

ISSN

2051-8153

e-ISSN

—

Svazek periodika

12

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

12

Strana od-do

1809-1820

Kód UT WoS článku

001416545400001

EID výsledku v databázi Scopus

2-s2.0-105001086794