Coupling of self-activating genes induces spontaneous synchronized oscillations in cells

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F47813059%3A19240%2F15%3A%230005515" target="_blank" >RIV/47813059:19240/15:#0005515 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Coupling of self-activating genes induces spontaneous synchronized oscillations in cells

Popis výsledku v původním jazyce

Genetic oscillators are present in a wide range of organisms from bacteria to neurons and coordinate important biological functions. Current models of genetic oscillators are based on auto-repressed genes. In these models a gene produces a repressor protein that binds to the promoter of its own gene repressing the transcription. Different versions of these models have been studied in living organisms and for engineering synthetic clocks. Synchronization of genetic clocks based on this model has also been studied. However, genes with positive feedbacks are also present in natural and synthetic genetic clocks. These self-activating genes provide robustness and frequency tuning to genetic clocks. In this paper we show a novel role of self-activating genes. We demonstrate that the coupling of self-activating genes by small molecules in a cell population produces synchronized oscillations. Our model could be useful for engineering new robust multicellular clocks and better understanding of

Název v anglickém jazyce

Coupling of self-activating genes induces spontaneous synchronized oscillations in cells

Popis výsledku anglicky

Genetic oscillators are present in a wide range of organisms from bacteria to neurons and coordinate important biological functions. Current models of genetic oscillators are based on auto-repressed genes. In these models a gene produces a repressor protein that binds to the promoter of its own gene repressing the transcription. Different versions of these models have been studied in living organisms and for engineering synthetic clocks. Synchronization of genetic clocks based on this model has also been studied. However, genes with positive feedbacks are also present in natural and synthetic genetic clocks. These self-activating genes provide robustness and frequency tuning to genetic clocks. In this paper we show a novel role of self-activating genes. We demonstrate that the coupling of self-activating genes by small molecules in a cell population produces synchronized oscillations. Our model could be useful for engineering new robust multicellular clocks and better understanding of

Druh

D - Stať ve sborníku

CEP obor

IN - Informatika

OECD FORD obor

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Projekt

<a href="/cs/project/ED1.1.00%2F02.0070" target="_blank" >ED1.1.00/02.0070: Centrum excelence IT4Innovations</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

BIOINFORMATICS 2015 - 6th International Conference on Bioinformatics Models, Methods and Algorithms, Proceedings

ISBN

9789897580703

ISSN

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e-ISSN

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Počet stran výsledku

7

Strana od-do

121-127

Název nakladatele

SciTePress

Místo vydání

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Místo konání akce

Lisbon

Datum konání akce

1. 1. 2015

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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