High-Dose Nitrate Supplementation Attenuates the Increased Blood Pressure Responses to Isometric Blood Flow Restriction Exercise in Healthy Males

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F49777513%3A23420%2F22%3A43965739" target="_blank" >RIV/49777513:23420/22:43965739 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.mdpi.com/2072-6643/14/17/3645" target="_blank" >https://www.mdpi.com/2072-6643/14/17/3645</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/nu14173645" target="_blank" >10.3390/nu14173645</a>

Jazyk výsledku

angličtina

Název v původním jazyce

High-Dose Nitrate Supplementation Attenuates the Increased Blood Pressure Responses to Isometric Blood Flow Restriction Exercise in Healthy Males

Popis výsledku v původním jazyce

The effect of nitrate (NO3 -) supplementation on blood pressure (BP) responses during large muscle mass isometric and ischaemic exercise in healthy young adults is unclear. The aim of the present study was to assess the effect of 5-day supplementation of NO3- on BP responses during a short isometric contraction and a sustained ischaemic contraction. In a randomised, doubleblinded, crossover design, 14 healthy active young adults underwent BP measurements after 5 days of either NO3- (NIT) or placebo (PLA) supplementation. Beat-by-beat BP was measured at preand post-exercise rest, and during a short (20 s) isometric contraction at 25% maximal strength and throughout a sustained ischaemic contraction. Plasma nitrite (NO2-) concentration increased significantly after NO3- supplementation compared to placebo. Systolic BP was significantly lower at pre- (p = 0.051) and post-exercise rest (p = 0.006), during a short isometric contraction (p = 0.030), and throughout a sustained ischaemic contraction (p = 0.040) after NO3- supplementation. Mean arterial pressure was significantly lower at pre- (p = 0.004) and post-exercise rest (p = 0.043), during a short isometric contraction (p = 0.041), and throughout a austained ischaemic contraction (p = 0.021) after NO3- supplementation. Diastolic BP was lower at pre-exercise rest (p = 0.032), but not at post-exercise rest, during a short isometric contraction, and during a sustained ischaemic contraction (all p &gt; 0.05). Five days of NO3- supplementation elevated plasma NO2- concentration and reduced BP during a short isometric contraction and a sustained ischaemic contraction in healthy adults. These observations indicate that multiple-day nitrate supplementation can decrease BP at rest and attenuate the increased BP response during isometric exercise. These findings support that NO3- supplementation is an effective nutritional intervention in reducing SBP and MAP in healthy young males during submaximal exercise.

Název v anglickém jazyce

High-Dose Nitrate Supplementation Attenuates the Increased Blood Pressure Responses to Isometric Blood Flow Restriction Exercise in Healthy Males

Popis výsledku anglicky

The effect of nitrate (NO3 -) supplementation on blood pressure (BP) responses during large muscle mass isometric and ischaemic exercise in healthy young adults is unclear. The aim of the present study was to assess the effect of 5-day supplementation of NO3- on BP responses during a short isometric contraction and a sustained ischaemic contraction. In a randomised, doubleblinded, crossover design, 14 healthy active young adults underwent BP measurements after 5 days of either NO3- (NIT) or placebo (PLA) supplementation. Beat-by-beat BP was measured at preand post-exercise rest, and during a short (20 s) isometric contraction at 25% maximal strength and throughout a sustained ischaemic contraction. Plasma nitrite (NO2-) concentration increased significantly after NO3- supplementation compared to placebo. Systolic BP was significantly lower at pre- (p = 0.051) and post-exercise rest (p = 0.006), during a short isometric contraction (p = 0.030), and throughout a sustained ischaemic contraction (p = 0.040) after NO3- supplementation. Mean arterial pressure was significantly lower at pre- (p = 0.004) and post-exercise rest (p = 0.043), during a short isometric contraction (p = 0.041), and throughout a austained ischaemic contraction (p = 0.021) after NO3- supplementation. Diastolic BP was lower at pre-exercise rest (p = 0.032), but not at post-exercise rest, during a short isometric contraction, and during a sustained ischaemic contraction (all p &gt; 0.05). Five days of NO3- supplementation elevated plasma NO2- concentration and reduced BP during a short isometric contraction and a sustained ischaemic contraction in healthy adults. These observations indicate that multiple-day nitrate supplementation can decrease BP at rest and attenuate the increased BP response during isometric exercise. These findings support that NO3- supplementation is an effective nutritional intervention in reducing SBP and MAP in healthy young males during submaximal exercise.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30308 - Nutrition, Dietetics

Projekt

<a href="/cs/project/EF18_054%2F0014627" target="_blank" >EF18_054/0014627: Rozvoj kapacit a prostředí pro posílení mezinárodní, mezisektorové a mezioborové spolupráce ZČU</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Nutrients

ISSN

2072-6643

e-ISSN

2072-6643

Svazek periodika

14

Číslo periodika v rámci svazku

17

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

11

Strana od-do

"Nestránkováno"

Kód UT WoS článku

000851637000001

EID výsledku v databázi Scopus

2-s2.0-85137564061