Noninvasive assessment of carotid artery stenoses by the principle of multiscale modelling of non-Newtonian blood flow in patient-specific models

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F49777513%3A23520%2F18%3A43932402" target="_blank" >RIV/49777513:23520/18:43932402 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.amc.2017.07.032" target="_blank" >http://dx.doi.org/10.1016/j.amc.2017.07.032</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.amc.2017.07.032" target="_blank" >10.1016/j.amc.2017.07.032</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Noninvasive assessment of carotid artery stenoses by the principle of multiscale modelling of non-Newtonian blood flow in patient-specific models

Popis výsledku v původním jazyce

The concept of geometrical multiscale modelling of non-Newtonian blood flow in patient-specific models is presented with the aim to provide a methodology for the assessment of hemodynamic significance of carotid artery stenoses. The content of the paper is divided into two consequent parts. In the first one, the principle of the fractional flow reserve (FFR) as an indicator of ischemia-inducing arterial stenoses is tested on three large arterial models containing the aortic arch and both left and right carotid arteries. Using the three-element Windkessel model as an outflow boundary condition, the blood flow simulations are carried out on the basis of data taken from the literature due to unavailable information on patient-specific flow and pressure waveforms. In the second part of the paper, the incorporation of real in-vivo measurements into the multiscale simulations is addressed by presenting a sequential algorithm for the estimation of Windkessel parameters. The ability of the described estimation method, which employs a non-linear state estimator (unscented Kalman filter) on zero-dimensional flow models, is demonstrated on two different patient-specific carotid bifurcation models.

Název v anglickém jazyce

Noninvasive assessment of carotid artery stenoses by the principle of multiscale modelling of non-Newtonian blood flow in patient-specific models

Popis výsledku anglicky

The concept of geometrical multiscale modelling of non-Newtonian blood flow in patient-specific models is presented with the aim to provide a methodology for the assessment of hemodynamic significance of carotid artery stenoses. The content of the paper is divided into two consequent parts. In the first one, the principle of the fractional flow reserve (FFR) as an indicator of ischemia-inducing arterial stenoses is tested on three large arterial models containing the aortic arch and both left and right carotid arteries. Using the three-element Windkessel model as an outflow boundary condition, the blood flow simulations are carried out on the basis of data taken from the literature due to unavailable information on patient-specific flow and pressure waveforms. In the second part of the paper, the incorporation of real in-vivo measurements into the multiscale simulations is addressed by presenting a sequential algorithm for the estimation of Windkessel parameters. The ability of the described estimation method, which employs a non-linear state estimator (unscented Kalman filter) on zero-dimensional flow models, is demonstrated on two different patient-specific carotid bifurcation models.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10305 - Fluids and plasma physics (including surface physics)

Projekt

<a href="/cs/project/LO1506" target="_blank" >LO1506: Podpora udržitelnosti centra NTIS - Nové technologie pro informační společnost</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

APPLIED MATHEMATICS AND COMPUTATION

ISSN

0096-3003

e-ISSN

—

Svazek periodika

319

Číslo periodika v rámci svazku

FEB 15 2018

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

19

Strana od-do

598-616

Kód UT WoS článku

000415906200048

EID výsledku v databázi Scopus

2-s2.0-85025691338