The role of boundary conditions and viscosity models in thrombosis modelling

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F49777513%3A23520%2F23%3A43969553" target="_blank" >RIV/49777513:23520/23:43969553 - isvavai.cz</a>

Výsledek na webu

<a href="http://hdl.handle.net/11025/54927" target="_blank" >http://hdl.handle.net/11025/54927</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The role of boundary conditions and viscosity models in thrombosis modelling

Popis výsledku v původním jazyce

The occlusive formation of a blood clot inside a blood vessel (thrombosis) is known as a very complex process based on many biological, biochemical and physical mechanisms. For this reason, model simplifications are often an essential part of the modelling process. However, even for a &apos;&apos;simple&apos;&apos; thrombosis model, one has to be aware that the choice of the blood flow model and the accompanying boundary conditions have the power to change the course of a simulation and consequently its outcome.To demonstrate the aforementioned simulation pitfalls, the present in-silico study is undertaken with the objective to assess the role of three keyfactors: injury extent, outlet pressure, and blood viscosity. For this purpose, the study employs an extended version of an earlier developed thrombosis model, which was modified by emphasising the central role of platelets in the formation of the primary haemostatic plug. The thrombosis simulations are carried out in representative vascular geometries and with respect to the complex blood flow dynamics often seen during thrombotic events.

Název v anglickém jazyce

The role of boundary conditions and viscosity models in thrombosis modelling

Popis výsledku anglicky

The occlusive formation of a blood clot inside a blood vessel (thrombosis) is known as a very complex process based on many biological, biochemical and physical mechanisms. For this reason, model simplifications are often an essential part of the modelling process. However, even for a &apos;&apos;simple&apos;&apos; thrombosis model, one has to be aware that the choice of the blood flow model and the accompanying boundary conditions have the power to change the course of a simulation and consequently its outcome.To demonstrate the aforementioned simulation pitfalls, the present in-silico study is undertaken with the objective to assess the role of three keyfactors: injury extent, outlet pressure, and blood viscosity. For this purpose, the study employs an extended version of an earlier developed thrombosis model, which was modified by emphasising the central role of platelets in the formation of the primary haemostatic plug. The thrombosis simulations are carried out in representative vascular geometries and with respect to the complex blood flow dynamics often seen during thrombotic events.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

20302 - Applied mechanics

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů