A preliminary in silico study of flow-mediated thrombosis in medical devices

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F49777513%3A23520%2F24%3A43972702" target="_blank" >RIV/49777513:23520/24:43972702 - isvavai.cz</a>

Výsledek na webu

<a href="https://link.springer.com/chapter/10.1007/978-3-031-70251-8_7" target="_blank" >https://link.springer.com/chapter/10.1007/978-3-031-70251-8_7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/978-3-031-70251-8_7" target="_blank" >10.1007/978-3-031-70251-8_7</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A preliminary in silico study of flow-mediated thrombosis in medical devices

Popis výsledku v původním jazyce

Failure of blood-contacting medical devices, such as vascular grafts and stents, is often attributed to thrombosis-related complications. To provide an alternative insight into the often very complex interaction between the forming clot and blood flow, the study introduces a continuum-based computational model based on a two-way coupled modelling approach. The basis of the model is formed by three interconnected submodels, each representing an essential part of the highly dynamic thrombosis process (blood clotting, fibrin polymerisation, and platelet plug formation). For the description of blood flow exposed to a coagulation trigger, a multiscale approach is used to ensure physiologically relevant flow conditions even during an imminent vessel blockage.

Název v anglickém jazyce

A preliminary in silico study of flow-mediated thrombosis in medical devices

Popis výsledku anglicky

Failure of blood-contacting medical devices, such as vascular grafts and stents, is often attributed to thrombosis-related complications. To provide an alternative insight into the often very complex interaction between the forming clot and blood flow, the study introduces a continuum-based computational model based on a two-way coupled modelling approach. The basis of the model is formed by three interconnected submodels, each representing an essential part of the highly dynamic thrombosis process (blood clotting, fibrin polymerisation, and platelet plug formation). For the description of blood flow exposed to a coagulation trigger, a multiscale approach is used to ensure physiologically relevant flow conditions even during an imminent vessel blockage.

Druh

D - Stať ve sborníku

CEP obor

—

OECD FORD obor

20302 - Applied mechanics

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Advances in Mechanism Design IV - Proceedings of TMM 2024

ISBN

978-3-031-70250-1

ISSN

2211-0984

e-ISSN

2211-0992

Počet stran výsledku

10

Strana od-do

66-75

Název nakladatele

Springer

Místo vydání

Cham

Místo konání akce

Liberec

Datum konání akce

3. 9. 2024

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

001328769400007