Evaluation of 11 polycyclic aromatic hydrocarbon metabolites in urine of Czech mothers and newborns

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12110%2F17%3A43891118" target="_blank" >RIV/60076658:12110/17:43891118 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378041:_____/17:00481918 RIV/60461373:22330/17:43913807

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.scitotenv.2016.10.165" target="_blank" >http://dx.doi.org/10.1016/j.scitotenv.2016.10.165</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.scitotenv.2016.10.165" target="_blank" >10.1016/j.scitotenv.2016.10.165</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Evaluation of 11 polycyclic aromatic hydrocarbon metabolites in urine of Czech mothers and newborns

Popis výsledku v původním jazyce

Polycyclic aromatic hydrocarbons (PAHs) represent a large group of ubiquitous contaminants of the environment, including food chain where they are released as by-products of incomplete combustion of an organic matter. Epidemiological studies have shown that exposure to PAHs correlated with increased incidence of cancer. Carcinogenicity is associated mainly with metabolites that are formed during metabolic degradation of these substances in exposed organism. In this study monohydroxylated PAHs (OH-PAH5), the major metabolites excreted into urine, were determined in 531 urine samples collected from mothers and their newborns from two localities of the Czech Republic - heavily air polluted Karvina and control locality of Ceske Budejovice and in two sampling rounds - August-October 2013 (summer, less air polluted season) and January-April 2014 (winter, more air polluted season). From all targeted analytes, naphthalene-2-ol was the most abundant compound present in 100% of the samples and it represented also the analyte with the highest concentration. Median concentration of Sigma OH-PAHs in the urine of children was on average 1.6 times lower compared to the respective mother which correlates with higher intake of PAHs by mothers. Sigma OH-PAHs concentrations determined in mothers' urine collected in the summer were comparable in both localities. No significant increase occurred in Ceske Budejovice in winter, while in samples from the Karvina region a statistically significant difference (alpha = 0.05) in the amount of Sigma OH-PAHs was observed. The median concentrations of Sigma OH-PAHs in mothers' urine samples in the winter were 1.5 times higher than in the summer in the same locality. The amounts of Sigma OH-PAHs in newborns' urine from Karvina in the winter season were 1.5 times higher than in the summer collected in the same locality and 3.3 times higher when compared with the less polluted locality of Ceske Budejovice.

Název v anglickém jazyce

Evaluation of 11 polycyclic aromatic hydrocarbon metabolites in urine of Czech mothers and newborns

Popis výsledku anglicky

Polycyclic aromatic hydrocarbons (PAHs) represent a large group of ubiquitous contaminants of the environment, including food chain where they are released as by-products of incomplete combustion of an organic matter. Epidemiological studies have shown that exposure to PAHs correlated with increased incidence of cancer. Carcinogenicity is associated mainly with metabolites that are formed during metabolic degradation of these substances in exposed organism. In this study monohydroxylated PAHs (OH-PAH5), the major metabolites excreted into urine, were determined in 531 urine samples collected from mothers and their newborns from two localities of the Czech Republic - heavily air polluted Karvina and control locality of Ceske Budejovice and in two sampling rounds - August-October 2013 (summer, less air polluted season) and January-April 2014 (winter, more air polluted season). From all targeted analytes, naphthalene-2-ol was the most abundant compound present in 100% of the samples and it represented also the analyte with the highest concentration. Median concentration of Sigma OH-PAHs in the urine of children was on average 1.6 times lower compared to the respective mother which correlates with higher intake of PAHs by mothers. Sigma OH-PAHs concentrations determined in mothers' urine collected in the summer were comparable in both localities. No significant increase occurred in Ceske Budejovice in winter, while in samples from the Karvina region a statistically significant difference (alpha = 0.05) in the amount of Sigma OH-PAHs was observed. The median concentrations of Sigma OH-PAHs in mothers' urine samples in the winter were 1.5 times higher than in the summer in the same locality. The amounts of Sigma OH-PAHs in newborns' urine from Karvina in the winter season were 1.5 times higher than in the summer collected in the same locality and 3.3 times higher when compared with the less polluted locality of Ceske Budejovice.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

DI - Znečištění a kontrola vzduchu

OECD FORD obor

—

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Science of the Total Environment

ISSN

0048-9697

e-ISSN

—

Svazek periodika

577

Číslo periodika v rámci svazku

2017

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

8

Strana od-do

212-219

Kód UT WoS článku

000390737400021

EID výsledku v databázi Scopus

—