A possible link between cognitive development in 5 years old children and prenatal oxidative stress

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12110%2F22%3A43905234" target="_blank" >RIV/60076658:12110/22:43905234 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.nel.edu/userfiles/articlesnew/1659462225_43_1_blazkova_27-pdf.pdf" target="_blank" >https://www.nel.edu/userfiles/articlesnew/1659462225_43_1_blazkova_27-pdf.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

A possible link between cognitive development in 5 years old children and prenatal oxidative stress

Popis výsledku v původním jazyce

To study the impact of oxidative damage associated with particulate matter&lt; 2.5 μm (PM2.5) during prenatal period on the cognitive development in five years old children. METHODS: Two cohorts of children aged five years, born in the years 2013 and 2014, were studied for their cognitive development in the polluted district Karvina and the control district Ceske Budejovice. Exposure to PM2.5 in the ambient air was measured for each mother during the 3 rd trimester of pregnancy. Oxidative damage was determined from the level of biomarkers at delivery in mothers ́and newborns ́ urine as 8-oxo-7,8-dihydro-2 ́-deoxyguanosine (8-oxodG) and in plasma as 15-F2t-isoprostane levels (15-F2t-IsoP). The Bender Visual Motor Gestalt Test (BG test) and the Raven Colored Progressive Matrices (RCPM test) were used as psychological cognitive tests.RESULTS: Average concentrations of PM2.5 ± SD in the 3rd trimester of mothers ́pregnancies were 37.7 ± 14.7 μg/m 3 and 17.1 ± 4.8 μg/m 3 in Karvina and Ceske Budejovice, respectively (p &lt; 0.001). The maternal level of 15-F2t-IsoP in plasma at the time of delivery was significantly associated with the results of the RCPM test (p &lt; 0.05) and the BG test (p &lt; 0.05) in five years old children.

Název v anglickém jazyce

A possible link between cognitive development in 5 years old children and prenatal oxidative stress

Popis výsledku anglicky

To study the impact of oxidative damage associated with particulate matter&lt; 2.5 μm (PM2.5) during prenatal period on the cognitive development in five years old children. METHODS: Two cohorts of children aged five years, born in the years 2013 and 2014, were studied for their cognitive development in the polluted district Karvina and the control district Ceske Budejovice. Exposure to PM2.5 in the ambient air was measured for each mother during the 3 rd trimester of pregnancy. Oxidative damage was determined from the level of biomarkers at delivery in mothers ́and newborns ́ urine as 8-oxo-7,8-dihydro-2 ́-deoxyguanosine (8-oxodG) and in plasma as 15-F2t-isoprostane levels (15-F2t-IsoP). The Bender Visual Motor Gestalt Test (BG test) and the Raven Colored Progressive Matrices (RCPM test) were used as psychological cognitive tests.RESULTS: Average concentrations of PM2.5 ± SD in the 3rd trimester of mothers ́pregnancies were 37.7 ± 14.7 μg/m 3 and 17.1 ± 4.8 μg/m 3 in Karvina and Ceske Budejovice, respectively (p &lt; 0.001). The maternal level of 15-F2t-IsoP in plasma at the time of delivery was significantly associated with the results of the RCPM test (p &lt; 0.05) and the BG test (p &lt; 0.05) in five years old children.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

30304 - Public and environmental health

Projekt

<a href="/cs/project/NV18-09-00151" target="_blank" >NV18-09-00151: Vliv znečištěného ovzduší na nemocnost dětí</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Neuroendocrinology Letters

ISSN

0172-780X

e-ISSN

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Svazek periodika

43

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

SE - Švédské království

Počet stran výsledku

12

Strana od-do

27-38

Kód UT WoS článku

000942359700004

EID výsledku v databázi Scopus

2-s2.0-85135350449