Encephalitozoon cuniculi Genotype II Concentrates in Inflammation Foci

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12220%2F20%3A43901278" target="_blank" >RIV/60076658:12220/20:43901278 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60077344:_____/20:00537265 RIV/60076658:12310/20:43901278 RIV/00064211:_____/20:W0000044

Výsledek na webu

<a href="https://www.dovepress.com/encephalitozoon-cuniculi-genotype-ii-concentrates-in-inflammation-foci-peer-reviewed-article-JIR" target="_blank" >https://www.dovepress.com/encephalitozoon-cuniculi-genotype-ii-concentrates-in-inflammation-foci-peer-reviewed-article-JIR</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2147/JIR.S271628" target="_blank" >10.2147/JIR.S271628</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Encephalitozoon cuniculi Genotype II Concentrates in Inflammation Foci

Popis výsledku v původním jazyce

Background: Microsporidia of the genus Encephalitozoon are generally connected with severe infections with lethal outcome in immunodeficient hosts. In immunocompetent hosts, microsporidiosis typically establishes a balanced host-parasite relationship that produces minimal clinically overt disease. Although the alimentary tract represents one of the main primary target tissues, the mechanisms of reaching other tissues during systemic microsporidian infections remain unclear. Methods: In the present study, we tested the relation between inflammation induction in immunocompetent and immunodeficient mice and the presence of spores of E. cuniculi genotype II in selected organs and in fecal specimens by using molecular and histology methods. Results: We reported the positive connection between inflammation induction and the significant increase of E. cuniculi genotype II occurrence in inflammation foci in both immunocompetent BALB/c and immunodeficient severe combined immunodeficient (SCID) mice in the acute phase of infection and the re-activation of latent microsporidial infection following inflammation induction in immunocompetent mice. Conclusion: The results imply possible involvement of immune cells serving as vehicles transporting E. cuniculi genotype II purposefully across the whole host body towards inflammation. With increasing number of records of infections, it is necessary to reconsider microsporidia as agents responsible for various pathologies. The elucidation of possible connection with pro-inflammatory immune responses represents an important challenge with consequences for human health and development of therapeutic strategies.

Název v anglickém jazyce

Encephalitozoon cuniculi Genotype II Concentrates in Inflammation Foci

Popis výsledku anglicky

Background: Microsporidia of the genus Encephalitozoon are generally connected with severe infections with lethal outcome in immunodeficient hosts. In immunocompetent hosts, microsporidiosis typically establishes a balanced host-parasite relationship that produces minimal clinically overt disease. Although the alimentary tract represents one of the main primary target tissues, the mechanisms of reaching other tissues during systemic microsporidian infections remain unclear. Methods: In the present study, we tested the relation between inflammation induction in immunocompetent and immunodeficient mice and the presence of spores of E. cuniculi genotype II in selected organs and in fecal specimens by using molecular and histology methods. Results: We reported the positive connection between inflammation induction and the significant increase of E. cuniculi genotype II occurrence in inflammation foci in both immunocompetent BALB/c and immunodeficient severe combined immunodeficient (SCID) mice in the acute phase of infection and the re-activation of latent microsporidial infection following inflammation induction in immunocompetent mice. Conclusion: The results imply possible involvement of immune cells serving as vehicles transporting E. cuniculi genotype II purposefully across the whole host body towards inflammation. With increasing number of records of infections, it is necessary to reconsider microsporidia as agents responsible for various pathologies. The elucidation of possible connection with pro-inflammatory immune responses represents an important challenge with consequences for human health and development of therapeutic strategies.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30102 - Immunology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Inflammation Research

ISSN

1178-7031

e-ISSN

—

Svazek periodika

13

Číslo periodika v rámci svazku

2020

Stát vydavatele periodika

AU - Austrálie

Počet stran výsledku

11

Strana od-do

583-593

Kód UT WoS článku

000575168200001

EID výsledku v databázi Scopus

2-s2.0-85091532713