A massive systematic infection of Encephalitozoon cuniculi genotype III in mice does not cause clinical signs
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12220%2F20%3A43901462" target="_blank" >RIV/60076658:12220/20:43901462 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/60077344:_____/20:00538180 RIV/60076658:12310/20:43901462
Výsledek na webu
<a href="https://reader.elsevier.com/reader/sd/pii/S1286457920301222?token=BDF86F3F3F74304FAD3617497645DA9D771DA9559AFF49784652CDC14D97AD5837244C6DD96186B3ECE7972DD7B762C2" target="_blank" >https://reader.elsevier.com/reader/sd/pii/S1286457920301222?token=BDF86F3F3F74304FAD3617497645DA9D771DA9559AFF49784652CDC14D97AD5837244C6DD96186B3ECE7972DD7B762C2</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.micinf.2020.06.004" target="_blank" >10.1016/j.micinf.2020.06.004</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
A massive systematic infection of Encephalitozoon cuniculi genotype III in mice does not cause clinical signs
Popis výsledku v původním jazyce
Encephalitozoon cuniculi genotype III disseminated intensively into most of the organs in all strains of mice, followed by a chronic infection with massive microsporidia persistence in immunodeficient mice and a partial decrease in C57Bl/6 mice. Treatment with 0.2 mg Albendazole/mouse/day temporarily reduces the number of affected organs in immunocompetent C57Bl/6 mice, but not in CD4(-/-) and CD8(-/-) mice. The application of medication temporarily decreased the spore burden at least by one order of magnitude in all groups. These results demonstrate that the E. cuniculi genotype III infection had a progressive course and surprisingly, Albendazole treatment had only a minimal effect. The E. cuniculi genotype III spore burden in individual organs reached up to 10(8) or 10(9) in immunocompetent or immunodeficient mice, respectively; however, these mice did not demonstrate any obvious clinical signs of microsporidiosis, and the immunodeficient mice survived longer. Our findings clearly show that the survival of mice does not correspond to spore burden, which provides new insight into latent microsporidiosis from an epidemiological point of view. (C) 2020 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
Název v anglickém jazyce
A massive systematic infection of Encephalitozoon cuniculi genotype III in mice does not cause clinical signs
Popis výsledku anglicky
Encephalitozoon cuniculi genotype III disseminated intensively into most of the organs in all strains of mice, followed by a chronic infection with massive microsporidia persistence in immunodeficient mice and a partial decrease in C57Bl/6 mice. Treatment with 0.2 mg Albendazole/mouse/day temporarily reduces the number of affected organs in immunocompetent C57Bl/6 mice, but not in CD4(-/-) and CD8(-/-) mice. The application of medication temporarily decreased the spore burden at least by one order of magnitude in all groups. These results demonstrate that the E. cuniculi genotype III infection had a progressive course and surprisingly, Albendazole treatment had only a minimal effect. The E. cuniculi genotype III spore burden in individual organs reached up to 10(8) or 10(9) in immunocompetent or immunodeficient mice, respectively; however, these mice did not demonstrate any obvious clinical signs of microsporidiosis, and the immunodeficient mice survived longer. Our findings clearly show that the survival of mice does not correspond to spore burden, which provides new insight into latent microsporidiosis from an epidemiological point of view. (C) 2020 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30303 - Infectious Diseases
Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2020
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Microbes and Infection
ISSN
1286-4579
e-ISSN
—
Svazek periodika
22
Číslo periodika v rámci svazku
9
Stát vydavatele periodika
NL - Nizozemsko
Počet stran výsledku
7
Strana od-do
467-473
Kód UT WoS článku
000583804400015
EID výsledku v databázi Scopus
2-s2.0-85087972476