Endogenous antipyretics: Neuropeptides and glucocorticoids

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F04%3A00004726" target="_blank" >RIV/60076658:12310/04:00004726 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60076658:12310/04:00005711 RIV/00216208:11310/04:6978

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Endogenous antipyretics: Neuropeptides and glucocorticoids

Popis výsledku v původním jazyce

Based on observations that fever is suppressed under several physiological circumstances the existence of endogenous antipyretically active molecules has been postulated. A large number of experimental and some clinical studies provided evidence that theneuropeptides arginine vasopressin (AVP), alpha- and gamma-melanocyte stimulating hormones (alpha-MSH, gamma-MSH) and adrenocorticotropic hormone (ACTH) as well as glucocorticoids are capable to antagonize febrile responses to pyrogens. Endogenous antipyresis is mediated by actions of these molecules within the central nervous system or, at least in some cases, by peripheral effects. Brain sites where endogenous antipyresis is activated include the septal area of the limbic system and the anterior hypothalamus. The precise neuronal mechanisms of how the aforementioned endogenous mediators cause a limitation or even suppression of fever are not known. There is, however, evidence that endogenous antipyretics cancel changes in neuronal ac

Název v anglickém jazyce

Endogenous antipyretics: Neuropeptides and glucocorticoids

Popis výsledku anglicky

Based on observations that fever is suppressed under several physiological circumstances the existence of endogenous antipyretically active molecules has been postulated. A large number of experimental and some clinical studies provided evidence that theneuropeptides arginine vasopressin (AVP), alpha- and gamma-melanocyte stimulating hormones (alpha-MSH, gamma-MSH) and adrenocorticotropic hormone (ACTH) as well as glucocorticoids are capable to antagonize febrile responses to pyrogens. Endogenous antipyresis is mediated by actions of these molecules within the central nervous system or, at least in some cases, by peripheral effects. Brain sites where endogenous antipyresis is activated include the septal area of the limbic system and the anterior hypothalamus. The precise neuronal mechanisms of how the aforementioned endogenous mediators cause a limitation or even suppression of fever are not known. There is, however, evidence that endogenous antipyretics cancel changes in neuronal ac

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2004

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Frontiers of Bioscience

ISSN

1093-9946

e-ISSN

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Svazek periodika

9

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

816-826

Kód UT WoS článku

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EID výsledku v databázi Scopus

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