Altered Serum Immunological and Biochemical Parameters and Microbiota Composition in Patients With AN During Realimentation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F21%3A00545000" target="_blank" >RIV/61388971:_____/21:00545000 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00023761:_____/21:N0000024 RIV/00216208:11110/21:10431395 RIV/00064165:_____/21:10431395 RIV/00216208:11310/21:10431395

Výsledek na webu

<a href="https://www.frontiersin.org/articles/10.3389/fnut.2021.680870/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fnut.2021.680870/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fnut.2021.680870" target="_blank" >10.3389/fnut.2021.680870</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Altered Serum Immunological and Biochemical Parameters and Microbiota Composition in Patients With AN During Realimentation

Popis výsledku v původním jazyce

Anorexia nervosa (AN) is a life-threatening psychiatric disorder with not well-described pathogenesis. Besides the genetic and sociological factors, autoimmunity is also considered to take part in AN pathogenesis. We evaluated general serological factors showing the physiological state of 59 patients with AN at hospital admission and their discharge. We detected the altered levels of some general biochemical and immunological parameters. We also detected decreased levels of appetite-regulating alpha-melanocyte stimulating hormone (alpha-MSH) in patients at hospital admission. Moreover, elevated anti-alpha-MSH IgM levels and decreased anti-alpha-MSH IgA levels were observed in patients with AN. Therefore, we analyzed the gut microbiota composition with special focus on alpha-MSH antigen-mimetic containing microbes from the Enterobacteriaceae family. We correlated gut bacterial composition with anti-alpha-MSH Ig levels and detected decreasing IgG levels with increasing alpha diversity. The upregulation of pro-inflammatory cytokines IL-6, IL-17, and TNF-alpha were detected in patients with AN both prior and after hospitalization. We also evaluated the treatment outcome and improvement was observed in the majority of patients with AN. We provide new data about various serum biochemical parameters and their changes during the patients' hospitalization, with emphasis on the immune system, and its possible participation in AN pathogenesis.

Název v anglickém jazyce

Altered Serum Immunological and Biochemical Parameters and Microbiota Composition in Patients With AN During Realimentation

Popis výsledku anglicky

Anorexia nervosa (AN) is a life-threatening psychiatric disorder with not well-described pathogenesis. Besides the genetic and sociological factors, autoimmunity is also considered to take part in AN pathogenesis. We evaluated general serological factors showing the physiological state of 59 patients with AN at hospital admission and their discharge. We detected the altered levels of some general biochemical and immunological parameters. We also detected decreased levels of appetite-regulating alpha-melanocyte stimulating hormone (alpha-MSH) in patients at hospital admission. Moreover, elevated anti-alpha-MSH IgM levels and decreased anti-alpha-MSH IgA levels were observed in patients with AN. Therefore, we analyzed the gut microbiota composition with special focus on alpha-MSH antigen-mimetic containing microbes from the Enterobacteriaceae family. We correlated gut bacterial composition with anti-alpha-MSH Ig levels and detected decreasing IgG levels with increasing alpha diversity. The upregulation of pro-inflammatory cytokines IL-6, IL-17, and TNF-alpha were detected in patients with AN both prior and after hospitalization. We also evaluated the treatment outcome and improvement was observed in the majority of patients with AN. We provide new data about various serum biochemical parameters and their changes during the patients' hospitalization, with emphasis on the immune system, and its possible participation in AN pathogenesis.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10606 - Microbiology

Projekt

<a href="/cs/project/NV17-28905A" target="_blank" >NV17-28905A: Úloha střevního mikrobiomu a autoimunitních mechanismů u pacientek s mentální anorexií</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Frontiers in Nutrition

ISSN

2296-861X

e-ISSN

2296-861X

Svazek periodika

8

Číslo periodika v rámci svazku

AUG 2 2021

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

11

Strana od-do

680870

Kód UT WoS článku

000685529300001

EID výsledku v databázi Scopus

2-s2.0-85112756423