Composites of yeast glucan particles and curcumin lead to improvement of dextran sulfate sodium-induced acute bowel inflammation in rats

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F21%3A43922313" target="_blank" >RIV/60461373:22340/21:43922313 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15640/21:73607265 RIV/00216224:14160/21:00121162

Výsledek na webu

<a href="https://doi.org/10.1016/j.carbpol.2020.117142" target="_blank" >https://doi.org/10.1016/j.carbpol.2020.117142</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.carbpol.2020.117142" target="_blank" >10.1016/j.carbpol.2020.117142</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Composites of yeast glucan particles and curcumin lead to improvement of dextran sulfate sodium-induced acute bowel inflammation in rats

Popis výsledku v původním jazyce

The goal of this work was to assess the usability of yeast glucan particles (GPs) as carriers for curcumin and determine the beneficial effect of a pharmacological composite of curcumin in GPs on dextran sulfate sodium induced colitis in rats. The assessment of the anti-inflammatory effect of particular substances was evaluated on the basis of the calculated disease activity index and by assessment of cytokines and enzymes from the gut tissue - tumor necrosis factor alpha (TNF-alpha), transforming growth factor beta 1, interleukin (IL)-1 beta, IL-6, IL-10, IL-17, catalase, superoxide dismutase 2, myeloperoxidase (MPO), and matrix metalloproteinase 9. Composites of GPs with incorporated curcumin showed promising results with the capability to lower symptoms of colitis and significantly decrease the production of pro-inflammatory cytokines TNF-alpha, IL-1 beta, IL-6, and the activity of MPO, as well. The anti-inflammatory effect of the composites was greater than those of pure GPs or curcumin.

Název v anglickém jazyce

Composites of yeast glucan particles and curcumin lead to improvement of dextran sulfate sodium-induced acute bowel inflammation in rats

Popis výsledku anglicky

The goal of this work was to assess the usability of yeast glucan particles (GPs) as carriers for curcumin and determine the beneficial effect of a pharmacological composite of curcumin in GPs on dextran sulfate sodium induced colitis in rats. The assessment of the anti-inflammatory effect of particular substances was evaluated on the basis of the calculated disease activity index and by assessment of cytokines and enzymes from the gut tissue - tumor necrosis factor alpha (TNF-alpha), transforming growth factor beta 1, interleukin (IL)-1 beta, IL-6, IL-10, IL-17, catalase, superoxide dismutase 2, myeloperoxidase (MPO), and matrix metalloproteinase 9. Composites of GPs with incorporated curcumin showed promising results with the capability to lower symptoms of colitis and significantly decrease the production of pro-inflammatory cytokines TNF-alpha, IL-1 beta, IL-6, and the activity of MPO, as well. The anti-inflammatory effect of the composites was greater than those of pure GPs or curcumin.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

10700 - Other natural sciences

Projekt

<a href="/cs/project/NV16-27522A" target="_blank" >NV16-27522A: Přírodní bioaktivní látky enkapsulované v glukanových mikročásticích jako biomateriál vhodný pro léčbu střevních zánětlivých onemocnění</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Carbohydrate Polymers

ISSN

0144-8617

e-ISSN

—

Svazek periodika

252

Číslo periodika v rámci svazku

15 January 2021

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

117142

Kód UT WoS článku

000596264200008

EID výsledku v databázi Scopus

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